{"id":"W2246407194","doi":"10.1016/j.toxrep.2015.12.008","title":"Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: Potential implications for neurodegenerative diseases","year":2016,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Aquatic Ecosystems and Phytoplankton Dynamics","field":"Environmental Science","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation des Etoiles","keywords":"Apoptosis; Inflammation; Viability assay; Proinflammatory cytokine; Neuroinflammation; Neurodegeneration; Immune system; Programmed cell death; Caspase; Chemistry; Microglia; In vivo; Biology; Cell biology; Pharmacology; Molecular biology; Immunology; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001737501,0.0001513056,0.0002214145,0.00004192942,0.0001380739,0.00001110801,0.00007710353,0.0001110435,0.00008886393],"category_scores_gemma":[0.0001525523,0.0001149174,0.00004611079,0.00007539494,0.0001667081,0.0001157554,0.000176222,0.00004904622,0.00001539275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532976,"about_ca_system_score_gemma":0.00002413652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000229882,"about_ca_topic_score_gemma":0.0005690407,"domain_scores_codex":[0.9987718,0.00009165335,0.0003452813,0.0004464631,0.0000783581,0.0002664199],"domain_scores_gemma":[0.9989975,0.0003645888,0.0002168432,0.0002888165,0.000008299628,0.00012397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000244447,0.0001078012,0.3415071,0.00003850333,0.0000118511,0.00004330869,0.00009205551,0.0002953807,0.6550539,0.0001864768,0.001443149,0.001196096],"study_design_scores_gemma":[0.0007634608,0.0002218499,0.8928192,0.00004035087,0.00003249587,0.0001589978,0.00001060069,0.0003757637,0.1020309,0.002001299,0.001241785,0.0003032935],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969915,0.00002308618,0.0009324956,0.0007122724,0.0002622047,0.0008519344,0.00004529072,0.000030784,0.0001505024],"genre_scores_gemma":[0.9984241,0.00001202151,0.0001945497,0.0002417339,0.00005199587,0.000381266,0.00001319476,0.00001691387,0.0006642828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5530229,"threshold_uncertainty_score":0.4686194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005302128440462119,"score_gpt":0.2193248784636475,"score_spread":0.2140227500231854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}