{"id":"W2246582920","doi":"10.1212/wnl.80.7_supplement.s31.005","title":"An Exploratory Analysis of Magnetic Resonance Imaging Outcomes in the DreaMS Trial: A Double-Blind, Placebo-Controlled, Phase 2, 26-Week Trial of a Selective Sphingosine 1-Phosphate Receptor Agonist ONO-4641 in Patients with Relapsing–Remitting Multiple Sclerosis (S31.005)","year":2013,"lang":"en","type":"article","venue":"Neurology","topic":"Hermeneutics and Narrative Identity","field":"Arts and Humanities","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Agonist; Placebo; Double blind; Magnetic resonance imaging; Exploratory analysis; Sphingosine-1-phosphate receptor; Partial agonist; Medicine; Internal medicine; Sphingosine-1-phosphate; Receptor; Anesthesia; Sphingosine; Radiology; Pathology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005616336,0.00225313,0.00349216,0.0005473976,0.0006927971,0.001257802,0.0009771093,0.001880768,0.003395323],"category_scores_gemma":[0.004874472,0.0007344892,0.002569955,0.0004053363,0.001872247,0.001208081,0.0007670044,0.002446201,0.0006082676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005709883,"about_ca_system_score_gemma":0.001479273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004376205,"about_ca_topic_score_gemma":0.0009978728,"domain_scores_codex":[0.9966175,0.002523244,0.000162137,0.0003075547,0.0001880055,0.0002016018],"domain_scores_gemma":[0.9965729,0.001078517,0.001120613,0.000426932,0.0002451139,0.0005560016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9872636,0.002689629,0.0009754074,0.0004224306,0.001354312,0.00002731916,0.00006289178,0.0002083143,0.00176781,0.00009574882,0.0003153301,0.004817114],"study_design_scores_gemma":[0.9110404,0.08304809,0.00328941,0.00002519077,0.0009036768,0.00003760483,0.00004499082,0.0003022983,0.0006461084,0.0001786752,0.0004564029,0.00002703431],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875265,0.002468077,0.001361338,0.0006370054,0.0002638798,0.004472045,0.001822258,0.0001034494,0.001345425],"genre_scores_gemma":[0.9838052,0.001201565,0.003813031,0.000776992,0.0003938854,0.006561879,0.001439079,0.00002721178,0.001981085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005616336,"threshold_uncertainty_score":0.02970237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633826681592027,"score_gpt":0.2573847952568524,"score_spread":0.2210465284409321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}