{"id":"W224659124","doi":"10.2174/1570162x1303150506184606","title":"The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat's Basic Region","year":2015,"lang":"en","type":"article","venue":"Current HIV Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Interleukin-7 receptor; Jurkat cells; Biology; Molecular biology; Transfection; Cell biology; CD8; Immunoprecipitation; T cell; Receptor; Cytotoxic T cell; Internalization; Cell culture; Biochemistry; Antigen; Immune system; IL-2 receptor; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002609342,0.0002130763,0.0002848214,0.0002652069,0.00070726,0.00006633162,0.0007127724,0.0001686207,0.00007374434],"category_scores_gemma":[0.0004692379,0.0001261691,0.0001193252,0.0006048876,0.0007644287,0.0001570326,0.0002639763,0.0007166229,0.0008647123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140249,"about_ca_system_score_gemma":0.0003372286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001127111,"about_ca_topic_score_gemma":0.00008114192,"domain_scores_codex":[0.9961031,0.001631138,0.0004627655,0.0004993231,0.0003263432,0.0009773427],"domain_scores_gemma":[0.9979054,0.0005500266,0.0001307248,0.0007474239,0.0005673232,0.00009905641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004105621,0.001178311,0.001832459,0.000225815,0.0001379796,0.00005684089,0.005888632,0.00004298121,0.1525177,0.007932327,0.7831685,0.04291281],"study_design_scores_gemma":[0.003750438,0.00157588,0.0008743282,0.0003028118,0.0000128975,0.00004447755,0.001338456,0.00002987116,0.1073136,0.003577966,0.8809585,0.0002207554],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606205,0.009081975,0.002401776,0.01406173,0.0009133574,0.01062883,0.0003115838,0.00006730273,0.001912989],"genre_scores_gemma":[0.9822208,0.0001867019,0.0001600641,0.00001127177,0.0001567309,0.001630614,0.0007332396,0.00003294112,0.01486758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09778998,"threshold_uncertainty_score":0.9999132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1252933124078681,"score_gpt":0.3847701696796844,"score_spread":0.2594768572718162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}