{"id":"W224659124","doi":"10.2174/1570162x1303150506184606","title":"The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat's Basic Region","year":2015,"lang":"en","type":"article","venue":"Current HIV Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Interleukin-7 receptor; Jurkat cells; Biology; Molecular biology; Transfection; Cell biology; CD8; Immunoprecipitation; T cell; Receptor; Cytotoxic T cell; Internalization; Cell culture; Biochemistry; Antigen; Immune system; IL-2 receptor; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000966178,0.0002134121,0.0001538764,0.00007184581,0.0001222906,0.0001785922,0.0001449655,0.0002585694,0.0009386727],"category_scores_gemma":[0.0001121638,0.0001482385,0.0001743871,0.0001152946,0.0001428735,0.0001346955,0.0001267622,0.0004042714,0.0005354199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166548,"about_ca_system_score_gemma":0.0002016115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006441563,"about_ca_topic_score_gemma":0.0006721347,"domain_scores_codex":[0.9998955,0.00002196478,0.000008399522,0.00001761312,0.0000339824,0.00002260618],"domain_scores_gemma":[0.9999323,0.0000158472,0.00001846208,0.00001073083,0.00000737966,0.00001520661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004587639,0.000006545092,0.000103999,0.00001146676,0.000001167334,0.00002787502,0.000006165303,0.00006284856,0.9993205,0.00003780475,0.00001068152,0.0003650934],"study_design_scores_gemma":[0.00001957444,0.000129794,0.003101618,0.000006166589,0.000008164979,0.0003506945,0.00001590359,0.001564056,0.9923372,0.00003877644,0.002424472,0.000003660998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954485,0.0006771647,0.003002977,0.00004844733,0.00001154711,0.00002259351,0.0001529499,0.00003018422,0.0006056965],"genre_scores_gemma":[0.9944101,0.0002581503,0.003646133,0.00003799816,0.000004753397,0.00001625532,0.0004539376,0.000009950867,0.001162743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009386727,"threshold_uncertainty_score":0.003140211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1252933124078681,"score_gpt":0.3847701696796844,"score_spread":0.2594768572718162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}