{"id":"W2247323713","doi":"10.1182/blood.v108.11.2176.2176","title":"In Vitro and In Vivo Activity of SKI-606, a Novel Abl/Src Inhibitor, Against Imatinib Resistant BCR-ABL+ Neoplastic Cells.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Dasatinib; Imatinib; Imatinib mesylate; Cancer research; Nilotinib; ABL; Biology; Kinase; Tyrosine kinase; Signal transduction; Cell biology; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003160299,0.000518798,0.0004488244,0.0003444812,0.0001508482,0.0002990576,0.0002353532,0.000354178,0.001856317],"category_scores_gemma":[0.0001440509,0.0002299529,0.0003880729,0.0002809691,0.0001651457,0.0001656589,0.0001254606,0.0007511904,0.000791762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000221387,"about_ca_system_score_gemma":0.0002506992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009732234,"about_ca_topic_score_gemma":0.001040768,"domain_scores_codex":[0.9997663,0.0000704656,0.00002672704,0.00003439536,0.00005527998,0.00004684934],"domain_scores_gemma":[0.9998555,0.00003890035,0.00003010005,0.00001817485,0.00001567781,0.00004151696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007494273,0.0005663711,0.0002490467,0.00009590341,0.00002165947,0.00004204929,0.00002496287,0.0002889458,0.9943092,0.00007159526,0.0002267077,0.003354134],"study_design_scores_gemma":[0.00019402,0.008141952,0.00494346,0.0000106363,0.00007990192,0.0003683327,0.00001591083,0.001329514,0.9820789,0.00003376849,0.002796639,0.000007136224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827113,0.008905373,0.001964165,0.0001845471,0.0001551954,0.00009554493,0.002079318,0.0001981688,0.003706445],"genre_scores_gemma":[0.9872919,0.004069745,0.001250668,0.00007762197,0.0000359568,0.00008059101,0.003767631,0.00003690281,0.003388882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001856317,"threshold_uncertainty_score":0.006210029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007279621329737113,"score_gpt":0.2242480080331802,"score_spread":0.2169683867034431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}