{"id":"W2248222071","doi":"10.1200/jco.2014.32.15_suppl.4041","title":"A phase II study of MK-2206, an allosteric inhibitor of AKT as second-line therapy for advanced gastric and gastroesophageal junction (GEJ) cancer: A SWOG Cooperative Group trial (S1005).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Gastroenterology; Cancer; Adverse effect; Anemia; Phases of clinical research; Oncology; Surgery; Toxicity; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002114696,0.001648448,0.00171249,0.0004544627,0.0003665314,0.0007796271,0.0007403532,0.001286051,0.003563887],"category_scores_gemma":[0.0006393215,0.0005314101,0.001071102,0.0004180326,0.0008901805,0.0005368326,0.0003665167,0.002760726,0.0008673919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007252141,"about_ca_system_score_gemma":0.001766649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001352663,"about_ca_topic_score_gemma":0.003070139,"domain_scores_codex":[0.9996338,0.000195632,0.0000158545,0.00004670854,0.00002738134,0.0000806558],"domain_scores_gemma":[0.999408,0.00008756867,0.0000903117,0.00004543938,0.00002848345,0.00034021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8385758,0.05968118,0.007908198,0.0008609699,0.0008200462,0.0003086468,0.00027397,0.001970075,0.02690006,0.0002539324,0.00426233,0.05818481],"study_design_scores_gemma":[0.719855,0.2654442,0.009292579,0.00002980011,0.0003441428,0.0002133042,0.0000442656,0.0008589114,0.001861456,0.0001087008,0.001930967,0.00001666169],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918251,0.001719898,0.0003915754,0.0004149592,0.0001087179,0.003012852,0.0009174473,0.00007205248,0.001537394],"genre_scores_gemma":[0.9833094,0.002479311,0.001761114,0.001239839,0.0002051698,0.003730283,0.003278584,0.00003620868,0.003959996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003563887,"threshold_uncertainty_score":0.01192236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06547192002458377,"score_gpt":0.4543494135352635,"score_spread":0.3888774935106797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}