{"id":"W2248508232","doi":"","title":"Screening of candidate adenovirus expressing shRNAs for functional recovery of dF508-CFTR","year":2010,"lang":"en","type":"article","venue":"DIAL (Catholic University of Leuven)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ΔF508; Small hairpin RNA; Transduction (biophysics); RNA interference; Gene silencing; Biology; Small interfering RNA; Medicine; Cell biology; Cystic fibrosis; Molecular biology; Gene; Cystic fibrosis transmembrane conductance regulator; Genetics; Transfection; Gene knockdown; RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066397,0.0004700584,0.0006227831,0.0005923457,0.0003084225,0.0004539088,0.0004233432,0.0003841665,0.001578672],"category_scores_gemma":[0.0004407352,0.0003012716,0.0004147883,0.0004130341,0.0002234283,0.0002005485,0.0002615711,0.0004953239,0.0006302554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005723062,"about_ca_system_score_gemma":0.0005360756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000946635,"about_ca_topic_score_gemma":0.001830314,"domain_scores_codex":[0.9995697,0.00008076193,0.0001008721,0.00006506371,0.0001115337,0.00007194166],"domain_scores_gemma":[0.9996106,0.0001574027,0.00005034205,0.00005525129,0.00008001186,0.00004650739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007033678,0.00007170805,0.0003248939,0.00005647824,0.000008271082,0.00005029213,0.00002681855,0.0001689451,0.9968429,0.0001601068,0.00005299319,0.002166186],"study_design_scores_gemma":[0.00004580364,0.001053358,0.001851664,0.00001211889,0.00004810258,0.0001697644,0.0000539652,0.001697689,0.9909378,0.00003788387,0.004082672,0.000009163045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970541,0.001637853,0.02021133,0.0001546551,0.00008356856,0.001530261,0.002488119,0.0002315576,0.003121766],"genre_scores_gemma":[0.9199499,0.002824906,0.06116064,0.0001515221,0.00001769676,0.0011504,0.006819429,0.0001048094,0.007820722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578672,"threshold_uncertainty_score":0.005639732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300019609307643,"score_gpt":0.2579056621331777,"score_spread":0.2349054660401012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}