{"id":"W2248588393","doi":"10.1021/acs.biochem.5b01306","title":"Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions","keywords":"Bacteriocin; Peptide sequence; Sequence motif; Lactococcus lactis; Chemistry; Stereochemistry; Biology; Crystallography; Antimicrobial; Biochemistry; Bacteria; Genetics; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006256584,0.0001643753,0.0001882178,0.000006346439,0.000117765,0.00003255178,0.0001475971,0.0001461381,0.0001205248],"category_scores_gemma":[0.00002263534,0.0000596687,0.00004069688,0.00009891163,0.0003606526,0.00008104194,0.00007066528,0.0001054646,8.136071e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003363074,"about_ca_system_score_gemma":0.00001295314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001953919,"about_ca_topic_score_gemma":0.0001559389,"domain_scores_codex":[0.9991226,0.00003388024,0.0001306581,0.0003192708,0.0001389876,0.0002546078],"domain_scores_gemma":[0.9996077,0.00004575782,0.0001279586,0.00009114368,0.00003580864,0.00009157943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001682634,0.00001770662,0.031909,0.00002798325,0.00000870819,0.000002448586,0.00002769307,4.725958e-8,0.9524404,0.0000336731,0.0000728843,0.01529113],"study_design_scores_gemma":[0.0002789814,0.0002356887,0.6410621,0.00007405812,0.00001246263,0.00001539638,0.00005975327,0.00002522889,0.3579334,0.00008283358,0.0000811393,0.0001390098],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983253,0.0002685294,0.000001789445,0.001026849,0.0000277071,0.0001126348,0.0001052368,0.00003100371,0.0001009191],"genre_scores_gemma":[0.9995189,0.00003284226,0.00008433683,0.00002490861,0.00006921602,0.000001960585,0.00000803727,0.000002179108,0.0002576444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6091531,"threshold_uncertainty_score":0.2433219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009682234023911137,"score_gpt":0.1879089431970116,"score_spread":0.1782267091731005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}