{"id":"W2248588393","doi":"10.1021/acs.biochem.5b01306","title":"Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions","keywords":"Bacteriocin; Peptide sequence; Sequence motif; Lactococcus lactis; Chemistry; Stereochemistry; Biology; Crystallography; Antimicrobial; Biochemistry; Bacteria; Genetics; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000767585,0.0001937807,0.0001038558,0.0001484078,0.0001365134,0.0001485143,0.0001841542,0.000282214,0.0008958456],"category_scores_gemma":[0.0002124595,0.00006741998,0.0001351128,0.000137366,0.0002245206,0.0001405328,0.00008837866,0.0003689498,0.0001404437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003095052,"about_ca_system_score_gemma":0.0001459235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00195799,"about_ca_topic_score_gemma":0.001104986,"domain_scores_codex":[0.9999639,0.000006503782,0.000001716242,0.000008187842,0.000008353204,0.00001137623],"domain_scores_gemma":[0.999898,0.00002472156,0.00003491669,0.000003774968,0.00001386288,0.00002473642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002894059,0.00003959047,0.0009107824,0.00003790199,0.000009990679,0.0002737081,0.0000782106,0.0009123146,0.9947068,0.0003361485,0.0001329474,0.002272133],"study_design_scores_gemma":[0.0004394561,0.00283658,0.1140205,0.00008860987,0.0001283705,0.00253237,0.0009979064,0.09362788,0.7689594,0.002046112,0.01419347,0.0001293996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974133,0.0003771071,0.001340981,0.000104253,0.000005738741,0.000004274243,0.00008225838,0.00001525419,0.0006568246],"genre_scores_gemma":[0.9975932,0.0001892348,0.001194661,0.00004396634,0.000003842268,0.000005026233,0.0004998351,0.000005068104,0.0004651461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00195799,"threshold_uncertainty_score":0.003893256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009682234023911137,"score_gpt":0.1879089431970116,"score_spread":0.1782267091731005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}