{"id":"W2249344155","doi":"10.1021/acs.biomac.5b00906","title":"Asialoglycoprotein Receptor-Mediated Gene Delivery to Hepatocytes Using Galactosylated Polymers","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Alberta Innovates - Health Solutions","keywords":"Asialoglycoprotein receptor; Gene delivery; Endocytosis; Transfection; Chemistry; Hepatocyte; Receptor-mediated endocytosis; HeLa; Biochemistry; Molecular biology; Cytotoxicity; In vitro; Gene; Cell; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000167081,0.0003055926,0.0002291949,0.0001414652,0.00008466109,0.00006312913,0.0003516077,0.000253082,0.00007032555],"category_scores_gemma":[0.0001384128,0.0003032622,0.0001569981,0.0002660754,0.00008990913,0.000009630264,0.0002248868,0.00007416303,0.0003486049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005745895,"about_ca_system_score_gemma":0.0002468546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004748428,"about_ca_topic_score_gemma":0.0000426373,"domain_scores_codex":[0.9982944,0.0001074244,0.0003115198,0.0005660004,0.0002457308,0.0004749722],"domain_scores_gemma":[0.9988028,0.000007834239,0.00009926696,0.0004417677,0.0002427662,0.0004055595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003350304,0.00005497253,0.0009608717,0.000005161529,0.0001105122,0.00003134451,0.00008282177,0.00003002356,0.9932362,0.000004084826,0.003628353,0.001520659],"study_design_scores_gemma":[0.0006301313,0.0005999873,0.0003029998,0.00002571601,0.00002122267,0.00005059715,0.0001379217,0.0001196768,0.9855604,0.00001078404,0.01211015,0.0004303779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955131,0.001706668,0.0014147,0.0001165394,0.0003357252,0.0003133498,0.0001013135,0.00005395752,0.0004446362],"genre_scores_gemma":[0.9952618,0.00006718504,0.003039166,0.0005672049,0.000261114,0.000026084,0.00044449,0.00005295707,0.0002799393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008481798,"threshold_uncertainty_score":0.9999419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186553366917141,"score_gpt":0.2647837964387896,"score_spread":0.2329182627696182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}