{"id":"W2249344155","doi":"10.1021/acs.biomac.5b00906","title":"Asialoglycoprotein Receptor-Mediated Gene Delivery to Hepatocytes Using Galactosylated Polymers","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Alberta Innovates - Health Solutions","keywords":"Asialoglycoprotein receptor; Gene delivery; Endocytosis; Transfection; Chemistry; Hepatocyte; Receptor-mediated endocytosis; HeLa; Biochemistry; Molecular biology; Cytotoxicity; In vitro; Gene; Cell; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356057,0.0003432938,0.0001853254,0.0001838815,0.00007518853,0.0002333195,0.0001376111,0.000179337,0.0003440169],"category_scores_gemma":[0.000122596,0.0001340768,0.0001794178,0.0001630195,0.0001664065,0.000250022,0.0001902602,0.000264744,0.0002416137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002815827,"about_ca_system_score_gemma":0.000196155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003356156,"about_ca_topic_score_gemma":0.0004139573,"domain_scores_codex":[0.9999123,0.00002146509,0.000006477264,0.00001994097,0.00002123562,0.00001871051],"domain_scores_gemma":[0.9999447,0.00001245982,0.00002193635,0.000005352922,0.000005763097,0.000009819013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002862906,0.000009231552,0.0000467701,0.00002498369,0.000003609757,0.00002382183,0.000006800276,0.00011824,0.9981981,0.00007197385,0.00001292458,0.001454885],"study_design_scores_gemma":[0.000006748272,0.0001421796,0.0003334873,0.000001608911,0.000007018151,0.00005897891,0.00000298626,0.0004433735,0.9983147,0.00001794545,0.0006684535,0.000002432037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798956,0.00193178,0.01584001,0.00006467436,0.00001429344,0.00006641657,0.0001251464,0.0001145522,0.00194767],"genre_scores_gemma":[0.9850401,0.001626466,0.01076129,0.00005930234,0.000009726371,0.00005526132,0.0001862611,0.00003211293,0.002229511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003440169,"threshold_uncertainty_score":0.002043068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186553366917141,"score_gpt":0.2647837964387896,"score_spread":0.2329182627696182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}