{"id":"W2249777914","doi":"10.1161/circ.130.suppl_2.15404","title":"Abstract 15404: Efficient and Persistent Transgene Expression by Minicircle Plasmid versus Standard Plasmid Using Ultrasound Targeted Microbubble Destruction","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Microbubbles; Transfection; Green fluorescent protein; Minicircle; Plasmid; Transgene; Gene delivery; Genetic enhancement; Molecular biology; In vivo; Cationic liposome; In vitro; Sonoporation; Biology; Cell biology; Medicine; DNA; Gene; Ultrasound; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605456,0.0002858407,0.0002431371,0.0002910336,0.00009035662,0.0002471556,0.0002449889,0.000346743,0.002368403],"category_scores_gemma":[0.0001739293,0.0001088944,0.0001988983,0.0001631502,0.0002329201,0.0002350764,0.0001605624,0.0003563401,0.0004053674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002784488,"about_ca_system_score_gemma":0.0002334775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004415999,"about_ca_topic_score_gemma":0.0005674898,"domain_scores_codex":[0.9998395,0.00002032725,0.00001710706,0.00004088481,0.00005399256,0.00002811878],"domain_scores_gemma":[0.9998662,0.00002840954,0.00004930719,0.00001141732,0.00002026224,0.00002427326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007664516,0.00002216269,0.00009322908,0.00002898297,0.000002338828,0.00001762496,0.00000511961,0.00001501185,0.998302,0.00005435862,0.00003617831,0.001346387],"study_design_scores_gemma":[0.00001115577,0.0005253091,0.001353486,0.000004793267,0.00001221876,0.0001729882,0.000006339102,0.0003092424,0.9963118,0.00001318124,0.001276814,0.000002502399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840229,0.001699215,0.01214504,0.0001202942,0.00005672591,0.00006980108,0.0003019846,0.0002267044,0.00135717],"genre_scores_gemma":[0.9768101,0.001068044,0.01393905,0.00006340409,0.00002524348,0.00009466754,0.001207909,0.00005512574,0.006736402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002368403,"threshold_uncertainty_score":0.007923067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127332427335224,"score_gpt":0.2123783798043427,"score_spread":0.1996451370708203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}