{"id":"W2249979977","doi":"10.1093/annonc/mdu438.51","title":"Antitumor Activity of Pembrolizumab (Pembro; Mk-3475) and Correlation with Programmed Death Ligand 1 (Pd-L1) Expression in a Pooled Analysis of Patients (Pts) with Advanced Non–Small Cell Lung Carcinoma (Nsclc)","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Cancer research; PD-L1; Internal medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392913,0.0001638394,0.0007910483,0.000378622,0.00003202795,0.000003329149,0.00005279351,0.0001017485,0.000006716599],"category_scores_gemma":[0.0000409047,0.000114996,0.00007254162,0.0004894365,0.0001014658,0.0001057586,0.00002670962,0.0001004203,1.793101e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005954034,"about_ca_system_score_gemma":0.0002704678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003607804,"about_ca_topic_score_gemma":0.0003868017,"domain_scores_codex":[0.9988765,0.0000868432,0.0003482029,0.0002852791,0.0001934096,0.0002097465],"domain_scores_gemma":[0.9985914,0.000130606,0.0005549179,0.0002358317,0.0003923262,0.00009493771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006289632,0.002105087,0.9549244,0.0003043817,0.0005827324,0.00001123898,0.001425258,0.0005608085,0.01007365,0.00001301676,0.00001334757,0.02369642],"study_design_scores_gemma":[0.01253202,0.00857184,0.9357005,0.0002260984,0.002277034,0.00000283995,0.0001467578,0.002737223,0.03762515,0.000006389171,0.00006773293,0.0001064696],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963701,0.0001488055,0.0009797032,0.00009984575,0.00002134609,0.000860333,0.00002653934,0.000008060152,0.001485313],"genre_scores_gemma":[0.997981,0.0000489005,0.001696769,0.00004678308,0.000008125706,0.00006586635,0.00008992405,0.00001550834,0.00004710076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0275515,"threshold_uncertainty_score":0.46894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161539545469136,"score_gpt":0.3261462411814098,"score_spread":0.3099922866344962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}