{"id":"W2250038003","doi":"10.1200/jco.2008.26.15_suppl.14581","title":"Clinical development of huARH460–16–2: A therapeutic antibody targeting the CD44 cancer stem cell antigen on high-incidence adenocarcinomas","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arius3D (Canada)","funders":"","keywords":"Medicine; Stem cell; CD44; Cancer; Cancer research; Pathology; Humanized antibody; Antibody; Immunology; Internal medicine; Cell; Biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001249262,0.0003686413,0.000701553,0.0002846664,0.0003169411,0.0005982168,0.0004267732,0.0007267485,0.002379021],"category_scores_gemma":[0.0006034488,0.0002242478,0.0003783904,0.0001876104,0.0003491579,0.0003825666,0.0002259345,0.001221539,0.00071318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006052586,"about_ca_system_score_gemma":0.0009251887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006097174,"about_ca_topic_score_gemma":0.001148914,"domain_scores_codex":[0.9997099,0.0001168827,0.00001854133,0.0000317032,0.00004779887,0.00007512615],"domain_scores_gemma":[0.9997545,0.00004253922,0.00001953087,0.00002963741,0.00003884719,0.0001149258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03441315,0.01886585,0.02465862,0.0006803673,0.0003870971,0.002017939,0.000554601,0.003874385,0.2995308,0.003566114,0.01205049,0.5994006],"study_design_scores_gemma":[0.0526453,0.3599976,0.07091921,0.0001710929,0.0006510894,0.007843606,0.0002691621,0.0111766,0.3352943,0.001648851,0.1593063,0.00007690127],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747585,0.005376601,0.002840114,0.001736301,0.0003123111,0.001880125,0.0003587086,0.0001626174,0.01257456],"genre_scores_gemma":[0.9876462,0.002246813,0.002832026,0.001074289,0.0001172552,0.0004938312,0.000976839,0.00002627204,0.004586433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379021,"threshold_uncertainty_score":0.007958651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1361689421780787,"score_gpt":0.4666692631040759,"score_spread":0.3305003209259972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}