{"id":"W2250040605","doi":"10.1074/jbc.m115.642991","title":"Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Kexin; PCSK9; LDL receptor; Proprotein convertase; Tetraspanin; Biology; Cell biology; Chemistry; Biochemistry; Cholesterol; Lipoprotein; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469235,0.0003174168,0.0002882638,0.0001866562,0.0002335835,0.0003289096,0.0001894847,0.0003864858,0.001369982],"category_scores_gemma":[0.0001560925,0.0001484755,0.0003744804,0.0001488845,0.0001839638,0.0002259278,0.0003256556,0.0007284554,0.0004985026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005743021,"about_ca_system_score_gemma":0.0001846658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004718497,"about_ca_topic_score_gemma":0.0004444566,"domain_scores_codex":[0.9995843,0.00004134144,0.0000416953,0.00008958334,0.0001530018,0.00009008512],"domain_scores_gemma":[0.999843,0.00001555546,0.00004717197,0.00001801782,0.00002675171,0.0000495019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006876182,0.00001049958,0.0001537343,0.00001605124,0.000006651509,0.00003701701,0.000006412159,0.00001202134,0.9993526,0.00004276956,0.00002059112,0.0002728889],"study_design_scores_gemma":[0.0000164511,0.0001314459,0.007601241,0.000005116923,0.00002103879,0.0004780294,0.0000267461,0.0007749932,0.9889998,0.0000456549,0.001895812,0.00000364575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967312,0.001017148,0.001236595,0.00009736677,0.00003824467,0.0000112847,0.0001812337,0.0000287962,0.0006581911],"genre_scores_gemma":[0.994121,0.0003920897,0.00117775,0.00006203855,0.00001177866,0.00002033874,0.0008004289,0.00001131404,0.00340338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369982,"threshold_uncertainty_score":0.004583061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209304433900273,"score_gpt":0.2559740211588685,"score_spread":0.2138809768198657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}