{"id":"W2251079969","doi":"10.1007/s13566-015-0227-2","title":"A phase II trial to evaluate single-dose stereotactic body radiation therapy (SBRT) prior to surgery for early-stage breast carcinoma: SIGNAL (stereotactic image-guided neoadjuvant ablative radiation then lumpectomy) trial","year":2015,"lang":"en","type":"article","venue":"Journal of Radiation Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"St Joseph's Health Care; London Health Sciences Centre; Western University","funders":"Lawson Health Research Institute","keywords":"Medicine; Lumpectomy; Breast cancer; Radiation therapy; Clinical endpoint; Regimen; Surgical oncology; Cosmesis; Mastectomy; Radiology; Surgery; Breast-conserving surgery; Stage (stratigraphy); Cancer; Randomized controlled trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001440292,0.001950852,0.002121281,0.000448096,0.00041159,0.00111669,0.0008932358,0.001632917,0.009036956],"category_scores_gemma":[0.001588716,0.0004894112,0.001677469,0.0003737573,0.001390133,0.001169988,0.0004515658,0.00368807,0.002306184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008605291,"about_ca_system_score_gemma":0.001593982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00124056,"about_ca_topic_score_gemma":0.003087949,"domain_scores_codex":[0.9996029,0.0002072944,0.00001356963,0.00007801285,0.00002748936,0.00007071338],"domain_scores_gemma":[0.9989803,0.0002261527,0.0001843985,0.00009787355,0.0000496096,0.000461571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.951893,0.01407574,0.001223015,0.0003852795,0.0008274614,0.00006684436,0.0001232693,0.001225038,0.008032002,0.0003425312,0.002141202,0.01966467],"study_design_scores_gemma":[0.8552059,0.13867,0.002781185,0.00002238452,0.0003937891,0.0000666566,0.00005313457,0.0005098421,0.0007406283,0.0003596407,0.001177883,0.00001895027],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893454,0.001256702,0.0007034552,0.001654923,0.0004307137,0.001727042,0.001666084,0.0001564877,0.003059243],"genre_scores_gemma":[0.9755961,0.002009065,0.002351128,0.002544927,0.0004501118,0.003455651,0.00398719,0.00007937085,0.00952651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009036956,"threshold_uncertainty_score":0.03023165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06169466957178103,"score_gpt":0.3694048996668443,"score_spread":0.3077102300950632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}