{"id":"W2252311410","doi":"10.1186/s12862-016-0594-3","title":"Emergence and evolution of yeast prion and prion-like proteins","year":2016,"lang":"en","type":"article","venue":"BMC Evolutionary Biology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Saccharomyces cerevisiae; Genetics; Amyloid (mycology); Population; Phenotype; Genome; Yeast; Gene; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342183,0.0001161875,0.0001184473,0.00005031496,0.00007808916,0.000002608105,0.00008948469,0.0001535371,0.00004296529],"category_scores_gemma":[0.0001316011,0.00008740823,0.00004450744,0.00005691553,0.0002537732,0.000008346078,0.0001776269,0.000030931,0.00000421402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001447765,"about_ca_system_score_gemma":0.000108397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003504104,"about_ca_topic_score_gemma":0.0000218614,"domain_scores_codex":[0.999126,0.00009853819,0.0001938901,0.0003436274,0.00005661911,0.0001813101],"domain_scores_gemma":[0.9995342,0.00001629481,0.0001012044,0.0001950493,0.00007318307,0.00008006993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001501088,0.00003152302,0.1724057,0.00003491033,0.0000178059,2.52519e-7,0.000008356987,0.000001277478,0.8089719,0.002076559,0.0003146559,0.01598697],"study_design_scores_gemma":[0.001541075,0.001061279,0.9327545,0.0001189166,0.00003717121,0.00008130749,0.00008357973,0.0001965587,0.03072933,0.006497105,0.02643871,0.0004604181],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9367364,0.03493363,0.02758884,0.0001619893,0.000119075,0.0003166748,0.00008165307,0.00001371295,0.00004805256],"genre_scores_gemma":[0.9928485,0.003806208,0.00302514,0.00002261044,0.0001126242,0.00003808899,0.00002895285,0.000009057488,0.000108828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7782425,"threshold_uncertainty_score":0.3564404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009312892834630252,"score_gpt":0.2408957101034314,"score_spread":0.2315828172688012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}