{"id":"W2252328048","doi":"10.1021/acs.jnatprod.5b00676","title":"Hydroxylation of Longiborneol by a <i>Clm2</i>-Encoded CYP450 Monooxygenase to Produce Culmorin in <i>Fusarium graminearum</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Plant Pathogens and Fungal Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada","keywords":"Monooxygenase; Hydroxylation; Cytochrome P450; Complementation; Fusarium; Stereoselectivity; Mutant; Biosynthesis; Chemistry; Stereochemistry; High-performance liquid chromatography; Liquid culture; Enantiomer; Gene; Biology; Biochemistry; Chromatography; Botany; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004940787,0.0001661361,0.0002686186,0.000125055,0.00001858581,0.00001718335,0.0002371917,0.00008413185,6.115585e-7],"category_scores_gemma":[0.001083401,0.000135876,0.00008055408,0.0003267551,0.000032741,0.00002454824,0.00007028084,0.000182599,0.000003190424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003263837,"about_ca_system_score_gemma":0.0002131282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001809448,"about_ca_topic_score_gemma":0.000005826096,"domain_scores_codex":[0.9986089,0.00008887018,0.0004779204,0.000282247,0.0003128557,0.0002291336],"domain_scores_gemma":[0.9986696,0.000009820603,0.0003089643,0.0002620185,0.0005707106,0.0001789418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006703607,0.0002171677,0.00256415,0.00003408849,0.00002877414,0.00003495054,0.00006543799,0.0003593734,0.9818513,0.000003633219,0.01355286,0.0006178921],"study_design_scores_gemma":[0.0008707921,0.0006461425,0.006288016,0.00003453092,0.00002923514,0.0001369598,0.00004560716,0.00007773698,0.9840304,0.00004028851,0.007602843,0.0001974204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921334,0.006001458,0.00004051998,0.0008675965,0.0004367534,0.0002633737,0.0001741816,0.000003911707,0.00007878814],"genre_scores_gemma":[0.997742,0.00009972246,0.0009751126,0.0001525901,0.0004396036,0.000003175358,0.0001610224,0.00001586512,0.0004109038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005950014,"threshold_uncertainty_score":0.5540863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121475581923957,"score_gpt":0.2382470454883057,"score_spread":0.2270322896690661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}