{"id":"W2252328048","doi":"10.1021/acs.jnatprod.5b00676","title":"Hydroxylation of Longiborneol by a <i>Clm2</i>-Encoded CYP450 Monooxygenase to Produce Culmorin in <i>Fusarium graminearum</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Plant Pathogens and Fungal Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada","keywords":"Monooxygenase; Hydroxylation; Cytochrome P450; Complementation; Fusarium; Stereoselectivity; Mutant; Biosynthesis; Chemistry; Stereochemistry; High-performance liquid chromatography; Liquid culture; Enantiomer; Gene; Biology; Biochemistry; Chromatography; Botany; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009930648,0.0006306448,0.000221801,0.0001744347,0.0001926468,0.0002860716,0.0002054292,0.0002257041,0.0005441036],"category_scores_gemma":[0.0001239649,0.0001204241,0.0002797713,0.0002151212,0.0001535135,0.0002014274,0.0002344595,0.0004553845,0.0003311713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007448802,"about_ca_system_score_gemma":0.000291134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002710098,"about_ca_topic_score_gemma":0.003697108,"domain_scores_codex":[0.9998878,0.00001815668,0.000008829967,0.00002850865,0.00002433688,0.00003233526],"domain_scores_gemma":[0.9999107,0.0000103954,0.00002623683,0.0000125489,0.00001401243,0.00002602754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004664202,0.00001515475,0.0002432146,0.00001329179,0.000003944199,0.00006824762,0.00001038263,0.00007194486,0.9985185,0.000038096,0.00002316329,0.0009473967],"study_design_scores_gemma":[0.000008186145,0.00009533574,0.003152345,0.000002782543,0.00000881084,0.0002703668,0.00002435818,0.000534953,0.993332,0.00003141097,0.002533783,0.000005664383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989646,0.001097051,0.006916073,0.0001270205,0.0000282694,0.00006143327,0.0007886736,0.0001345926,0.001200869],"genre_scores_gemma":[0.989488,0.0004065601,0.005594495,0.00006838071,0.000007101262,0.0000299128,0.002469146,0.00005232945,0.001884151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002710098,"threshold_uncertainty_score":0.005404532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121475581923957,"score_gpt":0.2382470454883057,"score_spread":0.2270322896690661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}