{"id":"W2252346101","doi":"10.1039/c5nr06757j","title":"Low generation polyamine dendrimers bearing flexible tetraethylene glycol as nanocarriers for plasmids and siRNA","year":2016,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal; HEC Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lipofectamine; Dendrimer; Nanocarriers; Transfection; Click chemistry; Combinatorial chemistry; Polyamine; Chemistry; Plasmid; Materials science; Biophysics; Drug delivery; DNA; Biochemistry; Organic chemistry; Biology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477064,0.0004258558,0.0002078252,0.0002124392,0.0001432219,0.0003200483,0.0002438063,0.0003416882,0.000599946],"category_scores_gemma":[0.000194907,0.0001968835,0.0001877736,0.0002431631,0.0002662851,0.0003087884,0.0001996267,0.0004461741,0.0006728561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005600973,"about_ca_system_score_gemma":0.0002901321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00061401,"about_ca_topic_score_gemma":0.0009534786,"domain_scores_codex":[0.999897,0.00001721743,0.00001206824,0.00002798225,0.00002541004,0.00002037552],"domain_scores_gemma":[0.9998546,0.00003106427,0.00004508682,0.00001996614,0.00002315066,0.00002618095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004165764,0.000006208329,0.00003994594,0.00001449306,0.000001385039,0.00002476643,0.000008806051,0.0001089306,0.998472,0.00015723,0.00002208064,0.001102405],"study_design_scores_gemma":[0.000007210519,0.00006317811,0.0001925327,0.000001548548,0.000004855154,0.00004586011,0.000002365232,0.0005197876,0.9980147,0.00002507514,0.001119174,0.000003616974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656532,0.001129615,0.02898063,0.0001581062,0.0000479762,0.0001610228,0.0003434744,0.0003531932,0.003172809],"genre_scores_gemma":[0.9736984,0.0006544196,0.0202476,0.00007023747,0.00001135637,0.0001191499,0.0003629197,0.00006690235,0.004768875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00061401,"threshold_uncertainty_score":0.004063785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332401082456037,"score_gpt":0.2536534326339441,"score_spread":0.2403294218093837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}