{"id":"W2252346101","doi":"10.1039/c5nr06757j","title":"Low generation polyamine dendrimers bearing flexible tetraethylene glycol as nanocarriers for plasmids and siRNA","year":2016,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal; HEC Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lipofectamine; Dendrimer; Nanocarriers; Transfection; Click chemistry; Combinatorial chemistry; Polyamine; Chemistry; Plasmid; Materials science; Biophysics; Drug delivery; DNA; Biochemistry; Organic chemistry; Biology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008202348,0.0001383882,0.0001145035,0.0000435518,0.0001029958,0.00002669806,0.0001071686,0.0001652155,0.00002568469],"category_scores_gemma":[0.00007311497,0.0001086126,0.00006741485,0.00004150416,0.00007769708,0.00001038319,0.00005578263,0.00003147088,0.00001541351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001746358,"about_ca_system_score_gemma":0.00006029011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002205009,"about_ca_topic_score_gemma":0.00003965448,"domain_scores_codex":[0.9991464,0.00001694839,0.0001525981,0.0003508475,0.00008961487,0.0002436122],"domain_scores_gemma":[0.9995713,0.00001604823,0.0000467859,0.0001966222,0.00007150691,0.00009769381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001148297,0.00002032826,0.0009573991,0.00001001779,0.00003344192,9.6371e-7,0.00002085386,0.000004236748,0.9801105,0.00003652013,0.003240987,0.01544995],"study_design_scores_gemma":[0.000817621,0.0006451426,0.0003564089,0.00002342517,0.00001580235,0.00001149992,0.00003514061,0.00004888496,0.9804145,0.00004646264,0.01741084,0.0001743216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944108,0.000483499,0.003816903,0.0002268537,0.0003027231,0.0002138132,0.00004178877,0.0000161977,0.000487448],"genre_scores_gemma":[0.9897754,0.0002949049,0.0005735494,0.0002669558,0.000329963,0.00005160539,0.00004710355,0.00002218851,0.008638305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01527562,"threshold_uncertainty_score":0.4429094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332401082456037,"score_gpt":0.2536534326339441,"score_spread":0.2403294218093837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}