{"id":"W2252412663","doi":"","title":"Phase I/II study of CTCE-9908, a novel anticancer agent that inhibits CXCR4, in patients with advanced solid cancers","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Juravinski Cancer Centre","funders":"","keywords":"Medicine; CXCR4; Toxicity; CXCR4 antagonist; Metastasis; Internal medicine; Pharmacology; Cancer; Receptor; Oncology; Cancer research; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001996232,0.0003006549,0.0005613012,0.0001918031,0.00006292897,0.000009351875,0.0001223969,0.00009320566,0.00005645767],"category_scores_gemma":[0.000006637982,0.0002475651,0.00008739126,0.0005485549,0.00007972294,0.00006144268,0.00005343488,0.0002737353,5.445891e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005270288,"about_ca_system_score_gemma":0.0002521229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003376002,"about_ca_topic_score_gemma":0.0004364955,"domain_scores_codex":[0.9979087,0.00002261858,0.000455545,0.000412553,0.0007238981,0.0004766883],"domain_scores_gemma":[0.9989985,0.00002203826,0.0002304576,0.0003726718,0.0002388693,0.0001374807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00913735,0.01728911,0.2794787,0.0002408058,0.001393491,0.0001089542,0.01020701,0.003097143,0.5233476,0.00001944429,0.00001709986,0.1556633],"study_design_scores_gemma":[0.07631627,0.01356859,0.0402314,0.0008779676,0.0007232339,0.000004321071,0.001966319,0.0005684135,0.8625287,0.000009354404,0.002485621,0.0007197653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949672,0.001143388,0.002235554,0.00009193338,0.0001698123,0.00120834,0.00002068854,0.0000267329,0.0001364014],"genre_scores_gemma":[0.9983583,0.0001253041,0.0004352185,0.0008591925,0.00004958728,0.00004698686,0.00001730687,0.00007015962,0.00003793558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3391811,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804750341984988,"score_gpt":0.3310237124490393,"score_spread":0.3029762090291894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}