{"id":"W2252412663","doi":"","title":"Phase I/II study of CTCE-9908, a novel anticancer agent that inhibits CXCR4, in patients with advanced solid cancers","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Juravinski Cancer Centre","funders":"","keywords":"Medicine; CXCR4; Toxicity; CXCR4 antagonist; Metastasis; Internal medicine; Pharmacology; Cancer; Receptor; Oncology; Cancer research; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071632,0.001510957,0.001630865,0.0004848123,0.0003816606,0.0007684409,0.0008018631,0.001183539,0.002820812],"category_scores_gemma":[0.0005727485,0.0006373373,0.0008248971,0.0003959408,0.0008378708,0.0005585121,0.0003329602,0.002591836,0.0007677627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008528904,"about_ca_system_score_gemma":0.001407418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009307425,"about_ca_topic_score_gemma":0.001635323,"domain_scores_codex":[0.9996791,0.0001327331,0.00001748073,0.00004761055,0.00004032321,0.00008283764],"domain_scores_gemma":[0.9995585,0.00006724555,0.0000726165,0.00003949612,0.00003332199,0.0002287828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.448239,0.1969966,0.01699016,0.0008057604,0.0008284919,0.0006837139,0.0004990132,0.005817551,0.2018856,0.0006965121,0.00616422,0.1203934],"study_design_scores_gemma":[0.1991892,0.776618,0.01085087,0.00002197808,0.0001887942,0.0003145236,0.00004919837,0.001587818,0.00800125,0.0001233154,0.003034605,0.00002045777],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939519,0.0007929569,0.0006237446,0.00021114,0.00006792696,0.00258804,0.0005667091,0.00008632275,0.00111131],"genre_scores_gemma":[0.9882234,0.0009473548,0.002178697,0.0004977833,0.0001099054,0.003035992,0.001878174,0.00003094134,0.003097836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002820812,"threshold_uncertainty_score":0.009436607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804750341984988,"score_gpt":0.3310237124490393,"score_spread":0.3029762090291894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}