{"id":"W2252575065","doi":"10.15252/msb.20156492","title":"Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation","year":2015,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":397,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Biotechnology and Biological Sciences Research Council; RIKEN; Medical Research Council; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Epigenetics; Chromatin; Library science; Biology; Humanities; Genetics; DNA; Computer science; Art; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001016317,0.0001291708,0.0001212518,0.0002165044,0.0001549211,0.0003970303,0.0001145073,0.0002051146,0.0006624227],"category_scores_gemma":[0.0002174513,0.0001774649,0.0001485204,0.0002804339,0.0003377098,0.000279457,0.0002638237,0.0002811288,0.00017066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719865,"about_ca_system_score_gemma":0.0001202759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005111471,"about_ca_topic_score_gemma":0.0007766352,"domain_scores_codex":[0.9999182,0.00001039454,0.000005559236,0.00002481593,0.00002143997,0.00001955993],"domain_scores_gemma":[0.9998431,0.00002935681,0.00006704707,0.00002025369,0.00001767431,0.00002248284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005730572,0.00001143554,0.003479966,0.0000305794,0.000006511277,0.00004271244,0.00005125527,0.001691059,0.9907861,0.0005529433,0.00002722986,0.003262946],"study_design_scores_gemma":[0.000009532877,0.0001907801,0.1498211,0.0000157989,0.00002154634,0.0002291251,0.0001728027,0.01887139,0.8274923,0.001251447,0.001899723,0.0000244976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936094,0.0003883473,0.005128922,0.00002560554,0.000003137927,0.000005794685,0.00006212276,0.00005140805,0.0007252608],"genre_scores_gemma":[0.9978448,0.00021258,0.001479204,0.00001223125,0.000001323842,0.000007014861,0.00006188849,0.0000113465,0.0003696184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006624227,"threshold_uncertainty_score":0.002215981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127553539157907,"score_gpt":0.2196581492160791,"score_spread":0.2083826138245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}