{"id":"W2252583923","doi":"10.1021/acs.est.5b05585","title":"Emerging Disinfection Byproducts, Halobenzoquinones: Effects of Isomeric Structure and Halogen Substitution on Cytotoxicity, Formation of Reactive Oxygen Species, and Genotoxicity","year":2016,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Water Treatment and Disinfection","field":"Environmental Science","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; China Scholarship Council; Alberta Health","keywords":"Cytotoxicity; Genotoxicity; Chemistry; Halogen; Chinese hamster ovary cell; Reactive oxygen species; Toxicity; Stereochemistry; Oxygen; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578185,0.0003019739,0.0001686111,0.0001801333,0.0001087094,0.0001805804,0.0001203971,0.0001583755,0.0005918465],"category_scores_gemma":[0.0001724035,0.00008356541,0.0001943528,0.0001827358,0.0001592617,0.000169133,0.0001480471,0.0002071423,0.0001095249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613278,"about_ca_system_score_gemma":0.0001452709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006063167,"about_ca_topic_score_gemma":0.001402528,"domain_scores_codex":[0.9998643,0.00002274209,0.00001040796,0.00003527484,0.00005274303,0.00001442327],"domain_scores_gemma":[0.9997976,0.00003340134,0.00007087793,0.00001694081,0.00006186076,0.00001922535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000731299,0.00001156906,0.002939353,0.00007757623,0.00001332351,0.00003747426,0.00002114437,0.0001031451,0.9934226,0.00001693312,0.00001250159,0.003271186],"study_design_scores_gemma":[0.000002135503,0.0005144031,0.0207408,0.000005112098,0.00002785847,0.0001836698,0.00004091252,0.0001949022,0.9774074,0.00002158938,0.0008572763,0.000003925784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933729,0.004294351,0.001418789,0.00003485231,0.000006994861,0.00001871886,0.0002468941,0.00001653605,0.0005899855],"genre_scores_gemma":[0.9943441,0.002641095,0.002026017,0.00004311132,0.000005522244,0.00001103154,0.0003157193,0.000006860069,0.000606432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006063167,"threshold_uncertainty_score":0.001979887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003437376550211279,"score_gpt":0.184585475491851,"score_spread":0.1811480989416397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}