{"id":"W2252583923","doi":"10.1021/acs.est.5b05585","title":"Emerging Disinfection Byproducts, Halobenzoquinones: Effects of Isomeric Structure and Halogen Substitution on Cytotoxicity, Formation of Reactive Oxygen Species, and Genotoxicity","year":2016,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Water Treatment and Disinfection","field":"Environmental Science","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; China Scholarship Council; Alberta Health","keywords":"Cytotoxicity; Genotoxicity; Chemistry; Halogen; Chinese hamster ovary cell; Reactive oxygen species; Toxicity; Stereochemistry; Oxygen; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321683,0.0001695754,0.0001805326,0.0002737213,0.0002448296,0.00001011163,0.0001313484,0.0001046694,0.00007500439],"category_scores_gemma":[0.00004953616,0.000120039,0.000024057,0.000502292,0.00228756,0.0007208759,0.0002302887,0.00006748188,0.00001001221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004210727,"about_ca_system_score_gemma":0.000005974088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006022609,"about_ca_topic_score_gemma":0.0000187598,"domain_scores_codex":[0.9987677,0.00002862834,0.0002065066,0.0004481536,0.0003006692,0.0002483079],"domain_scores_gemma":[0.9994748,0.00002921421,0.0002019413,0.00023062,0.000004163306,0.00005924216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002008222,0.0000867337,0.1566324,0.0000106724,0.000004442106,0.0000010135,0.000154573,0.00001932552,0.8332053,0.0002929467,0.000002220204,0.009570219],"study_design_scores_gemma":[0.0002773578,0.0002984026,0.3870883,0.00001892268,0.00001333241,0.00001478486,0.00004750782,0.00001974889,0.6109319,0.001157876,0.0000480857,0.00008381387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983221,0.00006756895,0.0007663856,0.0001253089,0.0000766444,0.0004051942,0.00001742549,0.00003689335,0.0001825164],"genre_scores_gemma":[0.9996106,0.0001403948,0.0001785795,0.000009116461,0.00001006987,0.00001119193,0.000005623333,0.000006775727,0.00002765869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2304559,"threshold_uncertainty_score":0.8428611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003437376550211279,"score_gpt":0.184585475491851,"score_spread":0.1811480989416397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}