{"id":"W2252595170","doi":"10.1371/journal.pone.0147390","title":"Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Agricultural Biotechnology Research Center, Academia Sinica; Scientific Instrument Center, SXU; Academia Sinica; National Science Council","keywords":"Gene silencing; Programmed cell death; Pancreatic cancer; Intracellular; Oxidative stress; Cancer research; Cell growth; Glutathione; Oncogene; Biology; Cancer cell; Cell biology; Chemistry; Cell; Molecular biology; Cancer; Biochemistry; Apoptosis; Cell cycle; Enzyme; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260717,0.0003164749,0.0002383519,0.0001628548,0.0001206721,0.0001695394,0.0001261879,0.000195546,0.0008061638],"category_scores_gemma":[0.00008714884,0.0001352421,0.000292504,0.0002224263,0.0001674018,0.0001346387,0.0001502228,0.0004457059,0.0001846063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046811,"about_ca_system_score_gemma":0.0002503719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006440943,"about_ca_topic_score_gemma":0.0008236757,"domain_scores_codex":[0.9998872,0.00001710103,0.0000138695,0.00002484107,0.00002548765,0.00003153114],"domain_scores_gemma":[0.9999639,0.000006693514,0.000008011096,0.000005685254,0.000004325492,0.00001150334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002360781,0.00004587762,0.0002060387,0.00004827543,0.000007318449,0.00006276817,0.00001848916,0.00005747662,0.9982042,0.00005812564,0.00004200085,0.001013217],"study_design_scores_gemma":[0.00003534939,0.000574083,0.002595373,0.00000327376,0.00002303515,0.0001900317,0.00003423669,0.0009025006,0.9935441,0.00002607321,0.002069184,0.000002960262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950256,0.001692831,0.001736972,0.0001009682,0.00004575107,0.00003073433,0.0002520329,0.00008454808,0.00103058],"genre_scores_gemma":[0.9944215,0.001364298,0.001345723,0.00004669978,0.000008919475,0.0000565353,0.0004649738,0.000007863786,0.002283497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008061638,"threshold_uncertainty_score":0.002696872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04186370695121239,"score_gpt":0.2595994753727583,"score_spread":0.217735768421546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}