{"id":"W2252595170","doi":"10.1371/journal.pone.0147390","title":"Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Agricultural Biotechnology Research Center, Academia Sinica; Scientific Instrument Center, SXU; Academia Sinica; National Science Council","keywords":"Gene silencing; Programmed cell death; Pancreatic cancer; Intracellular; Oxidative stress; Cancer research; Cell growth; Glutathione; Oncogene; Biology; Cancer cell; Cell biology; Chemistry; Cell; Molecular biology; Cancer; Biochemistry; Apoptosis; Cell cycle; Enzyme; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002937218,0.0003303626,0.0007803204,0.0002667355,0.0001213174,0.0000156878,0.00007999353,0.0002064184,0.0001026426],"category_scores_gemma":[0.0005518849,0.0002354979,0.00005944966,0.0002734992,0.0001818621,0.0003614701,0.0001021946,0.0002680748,0.00000867147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001630896,"about_ca_system_score_gemma":0.0001719228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00018169,"about_ca_topic_score_gemma":0.00002125161,"domain_scores_codex":[0.9976674,0.0002889075,0.0005886078,0.0005113143,0.0005228854,0.0004209139],"domain_scores_gemma":[0.9983822,0.0005018514,0.0003936241,0.0003299587,0.0001696262,0.0002227179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003581584,0.001420185,0.1300427,0.0007045685,0.0001340668,0.0001045654,0.005475944,4.994136e-7,0.8616708,0.00003579261,0.00003228066,0.00002042516],"study_design_scores_gemma":[0.005367342,0.0008705579,0.05633841,0.004880705,0.000264183,0.000004513388,0.0008118061,0.00003596925,0.9308714,0.000297189,0.000001028104,0.0002569315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965656,0.001120841,0.00002529556,0.00008621943,0.0000240847,0.001472148,0.0003963183,0.00005498472,0.0002544758],"genre_scores_gemma":[0.9974387,0.0003648894,0.001333,0.00005302563,0.0001541819,0.0002265363,0.000278291,0.00005229712,0.00009904876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07370434,"threshold_uncertainty_score":0.9603327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04186370695121239,"score_gpt":0.2595994753727583,"score_spread":0.217735768421546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}