{"id":"W2252684444","doi":"10.1007/s11999-016-4714-6","title":"Implant-delivered Alendronate Causes a Dose-dependent Response on Net Bone Formation Around Porous Titanium Implants in Canines","year":2016,"lang":"en","type":"article","venue":"Clinical Orthopaedics and Related Research","topic":"Orthopaedic implants and arthroplasty","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Montreal General Hospital","funders":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University; McGill University","keywords":"Medicine; Implant; Osseointegration; Apposition; Dentistry; Titanium; Intramedullary rod; Fixation (population genetics); Femur; Alendronic acid; Bisphosphonate; Surgery; Osteoporosis; Materials science; Anatomy; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003525072,0.0002969594,0.0004867806,0.0003318251,0.0001228368,0.0003113499,0.0002825128,0.0004387719,0.0006329236],"category_scores_gemma":[0.0004668438,0.0003194523,0.0003850038,0.000146572,0.0006762916,0.0002934282,0.0002717693,0.0005760155,0.0001604173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002574585,"about_ca_system_score_gemma":0.0001538711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000326874,"about_ca_topic_score_gemma":0.0007305653,"domain_scores_codex":[0.9996383,0.00005786587,0.00003582183,0.00007609212,0.0001117536,0.00008000537],"domain_scores_gemma":[0.99934,0.0002070789,0.0002403585,0.00008150868,0.00006297626,0.000067995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00117714,0.0001223957,0.0008092494,0.00007520271,0.000009406136,0.00009208802,0.00004738097,0.00006179792,0.9964966,0.00001513678,0.00001836689,0.001075291],"study_design_scores_gemma":[0.0001116596,0.01240749,0.02618621,0.00001083534,0.00008317756,0.0008734137,0.0001895682,0.0007799361,0.9583884,0.00005087875,0.0009060983,0.00001234984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988164,0.0004899488,0.0004170206,0.00001973659,0.000009286115,0.00001485504,0.00004021421,0.00001685744,0.0001756898],"genre_scores_gemma":[0.9983175,0.0002856458,0.0008219119,0.00003760092,0.000008978654,0.00002467728,0.0001125484,0.000009576011,0.0003816889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006329236,"threshold_uncertainty_score":0.002117276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07813628326568375,"score_gpt":0.3948670955843865,"score_spread":0.3167308123187027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}