{"id":"W2252798168","doi":"10.1021/acs.molpharmaceut.5b00934","title":"PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with <sup>68</sup>Ga-Labeled Benzenesulfonamides","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Leading Edge Endowment Fund","keywords":"Biodistribution; Chemistry; In vivo; Acetazolamide; Monomer; Spect imaging; Carbonic anhydrase; Cancer research; Trimer; Enzyme; Dimer; Biochemistry; Molecular biology; Nuclear medicine; Medicine; In vitro; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002095739,0.0002673151,0.0002593388,0.0001040507,0.00005666808,0.00001195733,0.0002005322,0.00006757521,0.00007517335],"category_scores_gemma":[0.00006950593,0.0002022888,0.0001384468,0.0001729116,0.0001849981,0.00001554872,0.000123001,0.0001134675,0.000005986582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002558284,"about_ca_system_score_gemma":0.0001048828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001219114,"about_ca_topic_score_gemma":0.000003255565,"domain_scores_codex":[0.9984174,0.0001339994,0.0003976072,0.0004161346,0.0003060544,0.0003287835],"domain_scores_gemma":[0.9988797,0.00002268186,0.000261626,0.0004383665,0.0002600947,0.000137537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003410339,0.0001619446,0.002201545,0.00009666129,0.00005741725,0.00004007688,0.00003760376,0.0004353173,0.9953858,0.00003536119,0.000582136,0.00062512],"study_design_scores_gemma":[0.002436736,0.0002414847,0.00009616328,0.0001964587,0.00009637378,0.00007383098,0.00007792874,0.0009064536,0.9855049,0.00002517868,0.01006788,0.0002765635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909076,0.001674523,0.006156623,0.0002038124,0.00007008082,0.0002542467,0.0000798028,0.00002699733,0.0006262898],"genre_scores_gemma":[0.9968786,0.0002785044,0.001817187,0.0005813551,0.00006347393,0.00002022229,0.00008336778,0.00005473895,0.0002225831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009880831,"threshold_uncertainty_score":0.8249099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0089272496118337,"score_gpt":0.2567134719467655,"score_spread":0.2477862223349318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}