{"id":"W2252861824","doi":"10.1021/acs.orglett.5b02677","title":"Formal Synthesis of (+)-Lasubine II and (−)-Subcosine II via Organocatalytic Michael Addition of a Ketone to an α-Nitrostyrene","year":2015,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Michael reaction; Chemistry; Ketone; Organocatalysis; Organic chemistry; Combinatorial chemistry; Catalysis; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008944106,0.0003440797,0.0001579147,0.000126149,0.0001610486,0.0002229193,0.0002606937,0.0001944329,0.001401136],"category_scores_gemma":[0.0001134635,0.0001316551,0.0001743123,0.0001622112,0.0002022653,0.0001794631,0.0002299283,0.0004102947,0.000544408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025117,"about_ca_system_score_gemma":0.0004472502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008092221,"about_ca_topic_score_gemma":0.001463566,"domain_scores_codex":[0.9999428,0.00000891262,0.000005443615,0.00001171551,0.00001196616,0.00001913317],"domain_scores_gemma":[0.9999583,0.00000444864,0.0000103647,0.000005449725,0.000007379964,0.00001402128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008063747,0.00004018245,0.00018367,0.0001709542,0.00001605096,0.0004797695,0.0001454059,0.0005642101,0.9881269,0.002891121,0.0002026772,0.007098477],"study_design_scores_gemma":[0.00002311655,0.000430015,0.0007437455,0.00001027406,0.00001524205,0.0004963308,0.00005268128,0.0004229705,0.9844528,0.000344201,0.01299262,0.00001599892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9356282,0.002707925,0.02948482,0.000206776,0.0001546807,0.0002585511,0.0007984859,0.0002492102,0.03051118],"genre_scores_gemma":[0.9853914,0.00150221,0.007671996,0.00005354751,0.00001602696,0.0000623158,0.0002781987,0.00002196452,0.005002335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401136,"threshold_uncertainty_score":0.00468725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465648207620934,"score_gpt":0.2350357165325188,"score_spread":0.2203792344563095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}