{"id":"W2252997710","doi":"10.1371/journal.ppat.1005428","title":"The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Viral replication; Virology; Innate immune system; Pattern recognition receptor; Virus; Viral entry; Hepatitis C virus; RNA; Cell biology; Nuclear transport; Nuclear export signal; RIG-I; MDA5; Cytoplasm; Immune system; Cell nucleus; Genetics; Gene; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002901583,0.0001573047,0.0002385173,0.00009361085,0.000212032,0.00001743558,0.000224561,0.0001855477,0.0003747397],"category_scores_gemma":[0.0004147003,0.0001004504,0.00008620457,0.00009975403,0.00009613431,0.0001244236,0.00006046139,0.0001236042,0.0002161522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004285148,"about_ca_system_score_gemma":0.00002848766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001901942,"about_ca_topic_score_gemma":0.0005158412,"domain_scores_codex":[0.9987091,0.0003229964,0.0003546806,0.0003084165,0.00005013209,0.0002547184],"domain_scores_gemma":[0.9990434,0.0002785904,0.0001738375,0.0003486203,0.0001288784,0.00002669319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003754527,0.0001099375,0.01418112,0.000008368464,0.0001244731,0.000001531056,0.0003927571,2.771677e-8,0.9261966,0.000006520506,0.000340302,0.05826291],"study_design_scores_gemma":[0.0007167854,0.000586879,0.09607217,0.0001322058,0.00008853756,0.00001117295,0.00005583659,0.000005933308,0.8994889,0.00003286412,0.002601571,0.0002071969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977499,0.0001708999,0.00001899791,0.0007654135,0.0002264746,0.000308227,0.000460451,0.00007571677,0.0002239177],"genre_scores_gemma":[0.9979846,0.001092426,0.00000890881,0.0002451862,0.00001773237,0.00003687369,0.0001193752,0.00002936439,0.0004654675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08189104,"threshold_uncertainty_score":0.4103137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847802085745701,"score_gpt":0.2473967569562187,"score_spread":0.2189187360987617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}