{"id":"W2252997710","doi":"10.1371/journal.ppat.1005428","title":"The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Viral replication; Virology; Innate immune system; Pattern recognition receptor; Virus; Viral entry; Hepatitis C virus; RNA; Cell biology; Nuclear transport; Nuclear export signal; RIG-I; MDA5; Cytoplasm; Immune system; Cell nucleus; Genetics; Gene; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122859,0.0003181221,0.0003027467,0.0002534817,0.0002997678,0.0008182384,0.0002997712,0.0003809551,0.001369798],"category_scores_gemma":[0.0002384989,0.0001955251,0.0004933402,0.0001383162,0.0004197915,0.0006089322,0.0007153255,0.0005767043,0.001046139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007223843,"about_ca_system_score_gemma":0.0004518339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005731013,"about_ca_topic_score_gemma":0.000769939,"domain_scores_codex":[0.9997228,0.00004495981,0.00002382007,0.00005726887,0.00008211393,0.00006905849],"domain_scores_gemma":[0.9997194,0.0000341737,0.00009398661,0.00005669359,0.00004095127,0.00005464068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007837061,0.00000895277,0.0002741554,0.00004249128,0.00000370278,0.00003623193,0.00001329911,0.00004298961,0.9978234,0.0003997164,0.00002889943,0.00124777],"study_design_scores_gemma":[0.00002556608,0.0002042038,0.01466177,0.00002736966,0.00001747363,0.000502229,0.00006808264,0.002630723,0.9757451,0.000401189,0.00569874,0.00001752829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624651,0.00878318,0.02237311,0.0003463399,0.00006893714,0.00005772419,0.0004490091,0.000489426,0.004967213],"genre_scores_gemma":[0.9916944,0.001180124,0.003842785,0.00007489292,0.00001155533,0.00002513501,0.0003942594,0.00004182455,0.002734959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369798,"threshold_uncertainty_score":0.005241275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847802085745701,"score_gpt":0.2473967569562187,"score_spread":0.2189187360987617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}