{"id":"W2253015953","doi":"10.1021/ml3000534","title":"Design and Synthesis of Potent, Selective Inhibitors of Matriptase","year":2012,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Proteases; Serine protease; Benzothiazole; Serine; Chemistry; Transmembrane protein; Enzyme; Biochemistry; Protease; Computational biology; Cancer research; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215716,0.0004904367,0.0004446885,0.0002563921,0.0001593907,0.0002697969,0.000526396,0.0003106481,0.001514518],"category_scores_gemma":[0.0001791188,0.0002308846,0.000242719,0.0001970824,0.000132853,0.0002939796,0.0002460284,0.0006704975,0.0006026366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003228733,"about_ca_system_score_gemma":0.0002848195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000267507,"about_ca_topic_score_gemma":0.0008285634,"domain_scores_codex":[0.9999089,0.00001156591,0.00001002614,0.00001616879,0.00002463205,0.00002868778],"domain_scores_gemma":[0.9999307,0.000009356851,0.00001978614,0.000004685809,0.00001004359,0.00002541506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002943871,0.0001941882,0.0001120579,0.0003100754,0.00003286108,0.0002761361,0.00005848089,0.002668319,0.975161,0.001635383,0.0006593189,0.01859772],"study_design_scores_gemma":[0.000458416,0.003238711,0.0008473417,0.00002859986,0.00006154514,0.0006166597,0.0000290054,0.006963451,0.9577113,0.00030169,0.02970564,0.00003764311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8879299,0.01959863,0.07309527,0.0005175241,0.0003028755,0.001361577,0.00177993,0.0006802963,0.01473416],"genre_scores_gemma":[0.9330135,0.01529398,0.03959962,0.0002542247,0.00008730395,0.0005936917,0.001522686,0.00005841985,0.00957645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001514518,"threshold_uncertainty_score":0.005066574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008741691612516016,"score_gpt":0.2242935361385023,"score_spread":0.2155518445259863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}