{"id":"W2253026689","doi":"10.4049/jimmunol.178.supp.88.4","title":"Immune modulation through silencing CD80 and CD86 in dendritic cells using siRNA (88.4)","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"CD86; CD80; Gene silencing; Immune system; Cell biology; Biology; Small interfering RNA; IL-2 receptor; T cell; Molecular biology; Transfection; Cytotoxic T cell; Immunology; Cell culture; CD40; Gene; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002064571,0.0003739762,0.0002877525,0.0001800052,0.0001312132,0.0003238879,0.0001774991,0.0003500289,0.0007949538],"category_scores_gemma":[0.00009894814,0.0001125328,0.0002472463,0.0001324435,0.0001982908,0.0001528642,0.0001615463,0.0005081146,0.0004402643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002030987,"about_ca_system_score_gemma":0.0002427857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002643727,"about_ca_topic_score_gemma":0.0003321261,"domain_scores_codex":[0.9998063,0.00002873396,0.00002775702,0.00003978585,0.00005088878,0.00004654477],"domain_scores_gemma":[0.99993,0.00001414652,0.00002046192,0.000008979548,0.00001438386,0.00001191738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003557867,0.00001965112,0.0000553258,0.00002854979,0.00000244826,0.000008569072,0.000003714145,0.00004190761,0.9988808,0.00005269783,0.00003256831,0.0008381211],"study_design_scores_gemma":[0.00001266494,0.0001044472,0.0004902534,0.000002536125,0.00001389351,0.0000405696,0.000004595576,0.0005362,0.9975666,0.00001626922,0.001210627,0.000001376988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809051,0.002034979,0.012503,0.0001900024,0.000114132,0.00009315707,0.0005105864,0.0002250825,0.003424041],"genre_scores_gemma":[0.9859957,0.001220294,0.008302329,0.0001595185,0.00002586799,0.0001085134,0.0005440572,0.00005028275,0.003593397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007949538,"threshold_uncertainty_score":0.00265938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754345987692341,"score_gpt":0.2620348359896733,"score_spread":0.2444913761127499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}