{"id":"W2253068585","doi":"10.1093/toxsci/kfv232","title":"Transcriptional Profiling of Dibenzo[<i>def,p</i>]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; King's College London; Cancer Research UK","keywords":"Aryl hydrocarbon receptor; Toxicogenomics; Spleen; Genotoxicity; Carcinogen; Biology; Chrysene; Toxicity; Chemistry; Molecular biology; Gene expression; Immunology; Biochemistry; Pyrene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000838711,0.0001929179,0.0001891948,0.0003071706,0.0001326984,0.0002047588,0.00007223071,0.0001674138,0.000947095],"category_scores_gemma":[0.0000819981,0.0001003883,0.0002308679,0.0002484809,0.0001643932,0.0001125847,0.0001600793,0.0003025035,0.0002864338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001719732,"about_ca_system_score_gemma":0.0001153275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007376714,"about_ca_topic_score_gemma":0.001523944,"domain_scores_codex":[0.9999011,0.000007044792,0.0000052221,0.00003891014,0.00002663067,0.00002116759],"domain_scores_gemma":[0.9999094,0.00001276813,0.00002710716,0.000006907392,0.00002228921,0.00002154423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005914647,0.000006304729,0.0008928931,0.00001282929,0.000002697665,0.00001142802,0.00001316728,0.0000188909,0.9985555,0.00001363978,0.00001173961,0.0004017908],"study_design_scores_gemma":[0.000008666236,0.0003559097,0.1820543,0.00001086873,0.00004298225,0.0002267976,0.0001474668,0.001168215,0.8133498,0.00007279252,0.002553327,0.000008856263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933652,0.0007915349,0.002204494,0.00006152881,0.000009223649,0.00001803289,0.002694305,0.00004764027,0.0008079571],"genre_scores_gemma":[0.9910212,0.0007136535,0.001480979,0.00009312285,0.000008378707,0.00004562974,0.003366258,0.00002420315,0.003246555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000947095,"threshold_uncertainty_score":0.003168344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06583686621103382,"score_gpt":0.312362587550466,"score_spread":0.2465257213394322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}