{"id":"W2253068585","doi":"10.1093/toxsci/kfv232","title":"Transcriptional Profiling of Dibenzo[<i>def,p</i>]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; King's College London; Cancer Research UK","keywords":"Aryl hydrocarbon receptor; Toxicogenomics; Spleen; Genotoxicity; Carcinogen; Biology; Chrysene; Toxicity; Chemistry; Molecular biology; Gene expression; Immunology; Biochemistry; Pyrene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006740409,0.0001980871,0.0002800321,0.00009238976,0.0001386544,0.00004168818,0.0004391091,0.0002066487,0.00002389954],"category_scores_gemma":[0.0002406174,0.0001487637,0.0001098904,0.0003766957,0.0002756909,0.00001785226,0.0001728748,0.0001349311,0.000005547402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006810053,"about_ca_system_score_gemma":0.0003306462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009274431,"about_ca_topic_score_gemma":0.0003389402,"domain_scores_codex":[0.9980647,0.0001725858,0.0004021802,0.0005545823,0.0004500676,0.0003558855],"domain_scores_gemma":[0.9993723,0.00003467088,0.0001231246,0.0001871578,0.0001263429,0.0001563729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001068271,0.0002779925,0.001354757,0.00001917224,0.00001093529,0.000008993816,0.0001501005,0.0005266131,0.9936277,0.003546343,0.00001065254,0.0003598689],"study_design_scores_gemma":[0.0006396461,0.002487119,0.006513938,0.00001539454,0.00001159244,0.000008463255,0.0004114962,0.001085624,0.9854358,0.002827243,0.000310986,0.0002526631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997147,0.0006555711,0.0007957182,0.0001706837,0.0001521725,0.0004992855,0.00001059554,0.00001623541,0.0005527768],"genre_scores_gemma":[0.9965789,0.00004333344,0.003010173,0.0001654625,0.00008992927,0.00005743006,0.00001680763,0.000007494236,0.0000304341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00819191,"threshold_uncertainty_score":0.6066407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06583686621103382,"score_gpt":0.312362587550466,"score_spread":0.2465257213394322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}