{"id":"W2253173155","doi":"10.1038/ncomms9391","title":"Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Hospital for Sick Children; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Toronto General Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Deutsche Forschungsgemeinschaft; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Deutsches Zentrum für Herz-Kreislaufforschung; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Connexin; Gene knockdown; Intercalated disc; Cell biology; Zebrafish; Morpholino; Gap junction; Small hairpin RNA; Internalization; Biology; Membrane protein; Chemistry; Cell culture; Membrane; Biochemistry; Cell; Intracellular; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228024,0.0001656765,0.0001150755,0.0001475499,0.0001518722,0.0002224571,0.00008840462,0.0002011815,0.0005698911],"category_scores_gemma":[0.000104444,0.00009526381,0.0001688136,0.00007921566,0.0001638867,0.0001658356,0.0002072239,0.0002032215,0.0001924358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001905516,"about_ca_system_score_gemma":0.00009792771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003263191,"about_ca_topic_score_gemma":0.0007609113,"domain_scores_codex":[0.9999388,0.000006510073,0.00000512104,0.00001801061,0.00001592326,0.0000155891],"domain_scores_gemma":[0.9999398,0.000007665981,0.00002324618,0.000005135472,0.000007091374,0.00001717207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002062949,0.000002563952,0.0006235866,0.00001069853,0.000002381425,0.0000395916,0.000008445671,0.00001740724,0.9984731,0.00005122835,0.00001172375,0.0007386815],"study_design_scores_gemma":[0.000009200234,0.0001294227,0.09807053,0.000009465568,0.00002767365,0.0009625024,0.00007745878,0.001351933,0.89621,0.0001457872,0.002997386,0.000008713781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947966,0.001591165,0.002670983,0.00005108467,0.00001582437,0.000004244523,0.00009080402,0.00004251834,0.0007368187],"genre_scores_gemma":[0.9974272,0.0004103507,0.001239766,0.00003843762,0.000003343083,0.000002645807,0.0001182102,0.000008320992,0.0007516685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005698911,"threshold_uncertainty_score":0.001906455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527933391689717,"score_gpt":0.2753897064101818,"score_spread":0.2501103724932846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}