{"id":"W2253408620","doi":"10.1124/mol.115.099689","title":"Potentiators of Defective ΔF508–CFTR Gating that Do Not Interfere with Corrector Action","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Biomedical Imaging and Bioengineering; National Eye Institute; Vertex Pharmaceuticals","keywords":"Potentiator; ΔF508; Action (physics); Gating; Chemistry; Cystic fibrosis transmembrane conductance regulator; Genetics; Biochemistry; Biology; Physics; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216198,0.0001521227,0.0003141838,0.0001640084,0.0000318085,0.000009563267,0.0001028203,0.00006883078,0.0001963671],"category_scores_gemma":[0.0001899133,0.0001234127,0.00007215156,0.0002225663,0.0001760699,0.00008710743,0.00008342889,0.0002969909,0.00002631357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897787,"about_ca_system_score_gemma":0.0001951684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006266007,"about_ca_topic_score_gemma":0.00001133342,"domain_scores_codex":[0.9986531,0.0001867501,0.0001767807,0.0002838053,0.0003941798,0.0003053578],"domain_scores_gemma":[0.9990596,0.0001073524,0.0001334943,0.0001573273,0.000306657,0.000235529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002672812,0.0001628418,0.01077963,0.0001159295,0.0002821115,0.000259231,0.0003024393,0.0002197293,0.9792238,0.00002634684,0.001123445,0.004831642],"study_design_scores_gemma":[0.003528311,0.001644858,0.004834998,0.00008265015,0.0002120852,0.0002112124,0.0006886649,0.0007098676,0.9864583,0.00003727367,0.001467681,0.0001240707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987479,0.0003504175,0.009754557,0.0002848578,0.0004289251,0.0005184762,0.000006649293,0.00004777875,0.001129354],"genre_scores_gemma":[0.9970171,0.00001245371,0.002402405,0.0002889494,0.00007093979,0.00005311904,0.00001318398,0.00003115323,0.0001106585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009538153,"threshold_uncertainty_score":0.5032625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04684233548738552,"score_gpt":0.3716873059614866,"score_spread":0.324844970474101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}