{"id":"W2253408620","doi":"10.1124/mol.115.099689","title":"Potentiators of Defective ΔF508–CFTR Gating that Do Not Interfere with Corrector Action","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Biomedical Imaging and Bioengineering; National Eye Institute; Vertex Pharmaceuticals","keywords":"Potentiator; ΔF508; Action (physics); Gating; Chemistry; Cystic fibrosis transmembrane conductance regulator; Genetics; Biochemistry; Biology; Physics; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007088113,0.0007585171,0.001374643,0.0005801714,0.0004960624,0.0007988795,0.001244446,0.001372394,0.01071964],"category_scores_gemma":[0.001402832,0.0004444431,0.000784457,0.00044603,0.000994161,0.0007205565,0.0005826142,0.003432576,0.001785013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005537996,"about_ca_system_score_gemma":0.001068614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290809,"about_ca_topic_score_gemma":0.001390945,"domain_scores_codex":[0.9990826,0.0001642709,0.0001161538,0.0001041376,0.000231763,0.0003011575],"domain_scores_gemma":[0.9989817,0.0003924913,0.0001191033,0.0001979132,0.00009355288,0.0002152432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001825779,0.0005551114,0.0002836253,0.0002010273,0.00007851429,0.0003258871,0.0001273891,0.0002569023,0.9887208,0.001885666,0.0008542245,0.00488507],"study_design_scores_gemma":[0.001095033,0.002621588,0.004194845,0.0000603776,0.0001530457,0.001363972,0.0001208311,0.001286657,0.9771603,0.000358794,0.01152756,0.00005690687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818782,0.001651637,0.002072457,0.0007944411,0.0005915821,0.0003310381,0.0008451001,0.0004671577,0.01136842],"genre_scores_gemma":[0.9897907,0.001253108,0.003117334,0.0003635145,0.0001702178,0.0002344205,0.0008630056,0.0001371473,0.004070533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01071964,"threshold_uncertainty_score":0.03586072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04684233548738552,"score_gpt":0.3716873059614866,"score_spread":0.324844970474101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}