{"id":"W2253724029","doi":"10.1002/bies.201500187","title":"Formula G1: Cell cycle in the driver's seat of stem cell fate determination","year":2016,"lang":"en","type":"review","venue":"BioEssays","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Epigenetics; Stem cell; Cell fate determination; Embryonic stem cell; Cell biology; Cell cycle; Regulator; Cellular differentiation; Cell potency; Transcription factor; Gene regulatory network; Regulation of gene expression; Transcriptional regulation; Cyclin-dependent kinase; Induced pluripotent stem cell; Cell; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006919522,0.0009929934,0.001274383,0.002073608,0.0003880169,0.001065758,0.001250988,0.001773068,0.003915402],"category_scores_gemma":[0.0006676892,0.0003044905,0.0003736439,0.00168213,0.001550218,0.0022346,0.0009849577,0.002667535,0.003814224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001340728,"about_ca_system_score_gemma":0.001138553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312851,"about_ca_topic_score_gemma":0.001695361,"domain_scores_codex":[0.9998316,0.00002872117,0.00002275725,0.0000396831,0.00005894478,0.00001829449],"domain_scores_gemma":[0.999721,0.0001167471,0.00004095051,0.00001197644,0.00007172783,0.00003751643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001019454,0.00002882653,0.0002103718,0.01144947,0.00004946766,0.0003350841,0.00008900571,0.0005228447,0.0041347,0.02688348,0.04177149,0.9144235],"study_design_scores_gemma":[0.000007329871,0.00003775022,0.0003707292,0.001141797,0.00003060183,0.0009053237,0.0000362678,0.00007239927,0.0005814866,0.0048956,0.9919063,0.0000145258],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001078836,0.9965772,0.0003261523,0.0005964774,0.0005441497,0.000004783113,0.00002032628,0.00001100367,0.001812072],"genre_scores_gemma":[0.001237362,0.9958102,0.0003485082,0.0004844596,0.0004590322,0.000007390227,0.0000392068,0.000004625171,0.001609251],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003915402,"threshold_uncertainty_score":0.0130983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132152412895442,"score_gpt":0.2595280500924489,"score_spread":0.2463128088029047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}