{"id":"W2253860014","doi":"10.1152/ajpheart.2001.280.3.h1160","title":"Influence of permeating ions on Kv1.5 channel block by nifedipine","year":2001,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Nifedipine; Chemistry; Extracellular; Biophysics; Ion channel; Ion; Block (permutation group theory); Stereochemistry; Biochemistry; Receptor; Calcium; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002599999,0.0004714954,0.0007026822,0.0002229656,0.0002039663,0.0005560393,0.0005697338,0.0004065838,0.001136424],"category_scores_gemma":[0.0008767321,0.0001852277,0.0002878398,0.0001630531,0.0004039861,0.0003448295,0.0002845985,0.0005342736,0.0002896487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004327164,"about_ca_system_score_gemma":0.000340699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002745745,"about_ca_topic_score_gemma":0.001920635,"domain_scores_codex":[0.9995353,0.0000892287,0.00005923044,0.00006623987,0.0001238846,0.0001261501],"domain_scores_gemma":[0.9995818,0.000188125,0.00007186983,0.00003482817,0.00005139422,0.00007207272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004367169,0.00004353082,0.0001811066,0.0000404482,0.00001177032,0.00006593841,0.00004815221,0.00009995494,0.9978524,0.00006273199,0.00004048131,0.001116706],"study_design_scores_gemma":[0.00003151853,0.0006312712,0.002431489,0.00001029257,0.00005239012,0.0001464693,0.00003525134,0.0009308832,0.994485,0.00002642448,0.00120676,0.00001225446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970402,0.0009199852,0.000658359,0.00006761697,0.00002911647,0.00002322993,0.0001706851,0.00006852653,0.00102225],"genre_scores_gemma":[0.9965989,0.0007296781,0.001504337,0.00004688208,0.0000207892,0.00002975528,0.0002893707,0.00004664785,0.0007335816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002745745,"threshold_uncertainty_score":0.005459547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008041770543765868,"score_gpt":0.2365355495497009,"score_spread":0.228493779005935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}