{"id":"W2253908101","doi":"10.1021/acs.analchem.5b04010","title":"Utilizing a Key Aptamer Structure-Switching Mechanism for the Ultrahigh Frequency Detection of Cocaine","year":2016,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Chemistry; Detection limit; Context (archaeology); SIGNAL (programming language); Nanotechnology; Biosensor; Computer science; Chromatography; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331356,0.0001550878,0.0001741483,0.00001566265,0.00009112425,0.00001085169,0.0001730568,0.0001861999,0.000006580469],"category_scores_gemma":[0.0004229768,0.00008578964,0.0001907717,0.00009231739,0.0001191793,0.000004052597,0.0000424145,0.00007995866,3.256714e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001843612,"about_ca_system_score_gemma":0.00002608807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001284419,"about_ca_topic_score_gemma":0.00001387193,"domain_scores_codex":[0.9990778,0.00001390793,0.0002543078,0.0003130324,0.0001304,0.0002105445],"domain_scores_gemma":[0.9991868,0.00008021708,0.0001255372,0.0003672007,0.0001863472,0.00005396455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004262222,0.00001469094,0.00006280776,0.00002096543,0.0001076222,4.689142e-7,0.000003568851,4.064524e-7,0.9944009,0.0004563197,0.00002402781,0.004865605],"study_design_scores_gemma":[0.0002305339,0.00006358585,0.00003746592,0.00002616097,0.0001207342,0.00001204916,0.00004125408,0.0003729052,0.9951014,0.003359303,0.0004934936,0.0001410942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7033269,0.000159882,0.295352,0.0005248005,0.00004289865,0.0001421559,0.00005980187,0.00003900018,0.0003526037],"genre_scores_gemma":[0.9972932,0.00008237978,0.002011463,0.0001101472,0.000212309,0.000007085557,0.00001545856,0.00001705927,0.0002508655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2939664,"threshold_uncertainty_score":0.34984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016884294356417,"score_gpt":0.2628706664195744,"score_spread":0.2527018234760102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}