{"id":"W2253947615","doi":"10.1128/iai.00843-15","title":"Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence","year":2016,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Yersinia bacterium, plague, ectoparasites research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Yersinia pseudotuberculosis; Biology; Microbiology; Effector; Yersinia; Yersinia pestis; Mutant; Type three secretion system; Inflammasome; Innate immune system; Secretion; Virulence; Cell biology; Immune system; Inflammation; Bacteria; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532044,0.0003716001,0.0002878809,0.0002487191,0.0001704806,0.0002684353,0.0003034544,0.0004060966,0.000904776],"category_scores_gemma":[0.000144418,0.0001511176,0.0002669893,0.0001828107,0.0003005745,0.0002519647,0.0004033321,0.0004884586,0.000196924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511035,"about_ca_system_score_gemma":0.0002586497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004832789,"about_ca_topic_score_gemma":0.0006206825,"domain_scores_codex":[0.9998931,0.00002061792,0.00001288693,0.00002071499,0.00002641493,0.00002620279],"domain_scores_gemma":[0.9998753,0.00002307804,0.0000413059,0.00001415097,0.00001147764,0.00003458667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013034,0.00001404194,0.0003091826,0.00002130991,0.000002275798,0.00009138523,0.000008672331,0.00004546859,0.998957,0.00007018419,0.000007203314,0.0003718833],"study_design_scores_gemma":[0.00006013249,0.0004683465,0.036029,0.00001497667,0.00003675215,0.001577412,0.0001987023,0.004345608,0.955299,0.0002750086,0.001680834,0.00001419653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969086,0.0004420477,0.002018222,0.0001070153,0.000008673139,0.00001231294,0.0001514648,0.00002999757,0.000321644],"genre_scores_gemma":[0.9969077,0.0002574259,0.001920867,0.00003165974,0.000003632807,0.00001742596,0.0001468032,0.00000913232,0.0007052608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000904776,"threshold_uncertainty_score":0.003026724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161883740269386,"score_gpt":0.2812717263499798,"score_spread":0.2696528889472859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}