{"id":"W2254051095","doi":"10.1038/ncomms9859","title":"Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; SickKids Foundation; Hospital for Sick Children; Princess Margaret Cancer Centre; Canada Research Chairs","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Dephosphorylation; Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; MAPK/ERK pathway; Phosphorylation; Cancer research; GTPase; Phosphatase; Biology; Small GTPase; Activator (genetics); Anti-apoptotic Ras signalling cascade; Carcinogenesis; Cell growth; Kinase; Glioma; Signal transduction; Effector; Cell biology; Cancer; Biochemistry; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001805276,0.00008275156,0.0001182764,0.00004772506,0.000037407,0.000004455298,0.0003861747,0.0002357241,0.000004636],"category_scores_gemma":[0.0008811235,0.00008428092,0.00005003821,0.0001977117,0.0001479751,0.000007670556,0.0002673529,0.000132719,0.000002758733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001354452,"about_ca_system_score_gemma":0.0001347004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005674474,"about_ca_topic_score_gemma":0.0001720377,"domain_scores_codex":[0.9993361,0.00009372144,0.0002356881,0.0001194717,0.0001345269,0.0000804674],"domain_scores_gemma":[0.9981441,0.00005779,0.0001936461,0.00108938,0.0004662681,0.00004879016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011326,0.000248165,0.010992,0.00002708135,0.00005889932,2.497538e-7,0.00009154988,0.00006051866,0.9734583,0.003998004,0.009693276,0.001258675],"study_design_scores_gemma":[0.0003725766,0.00009471098,0.00425037,0.00001995224,0.00002430346,0.000001822866,0.00005590583,0.00003662297,0.9775805,0.0001599829,0.01732327,0.00007998467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8275995,0.1674618,0.0009564929,0.0009098553,0.000142182,0.00052289,0.0006599245,0.00003310092,0.001714326],"genre_scores_gemma":[0.9907756,0.0009437516,0.005755618,0.00007408731,0.00002379618,0.00002945947,0.002367956,0.00001253174,0.00001714278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.166518,"threshold_uncertainty_score":0.3436876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166474953791188,"score_gpt":0.2933263509766934,"score_spread":0.2716616014387815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}