{"id":"W2254287415","doi":"10.1093/jac/dkv176","title":"Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout","year":2015,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Dolutegravir; Raltegravir; Integrase; Integrase inhibitor; Virology; Pharmacology; Reverse transcriptase; Viral replication; Drug; Chemistry; Medicine; Virus; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603309,0.0004638205,0.0007907516,0.000252345,0.0002472183,0.0006797693,0.0005937973,0.0003364399,0.002049916],"category_scores_gemma":[0.0003890017,0.0002268845,0.0003890898,0.0002033934,0.0002797753,0.0002805545,0.0003548338,0.0007447841,0.00128954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003824436,"about_ca_system_score_gemma":0.0004477181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133316,"about_ca_topic_score_gemma":0.002825951,"domain_scores_codex":[0.9996949,0.00005435816,0.00003473863,0.0000710023,0.0000966394,0.00004840237],"domain_scores_gemma":[0.9996561,0.00008829372,0.00006323357,0.00009570073,0.00005775993,0.00003889952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000239895,0.00007457841,0.00034127,0.00006894606,0.00001269778,0.00007282816,0.00003227144,0.0001409303,0.9940049,0.00006135612,0.0001031853,0.004847103],"study_design_scores_gemma":[0.00007096182,0.00110817,0.004980388,0.00002488916,0.00002950536,0.0004571952,0.00006254511,0.001057152,0.983123,0.0000579415,0.009012767,0.0000155255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796407,0.006732293,0.006368281,0.0002542938,0.00007097159,0.00010586,0.001666607,0.0004650457,0.004696079],"genre_scores_gemma":[0.9753464,0.002794564,0.00868867,0.0001802648,0.00004690548,0.0001285753,0.003585331,0.0001547932,0.009074565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049916,"threshold_uncertainty_score":0.006857693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007820138784715847,"score_gpt":0.2712968158575478,"score_spread":0.263476677072832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}