{"id":"W2254323136","doi":"10.1093/toxsci/kfv243","title":"An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe<sup>−/−</sup>Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada","keywords":"Medicine; Inflammation; COPD; Lung; Smoking cessation; Nicotine; Inhalation; Physiology; Metaplasia; Inhalation exposure; Pathology; Tobacco smoke; Internal medicine; Toxicity; Anesthesia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002684586,0.0002295407,0.0006707475,0.0003073983,0.0001776728,0.00006808912,0.0002866266,0.0001048488,0.00001192779],"category_scores_gemma":[0.000998194,0.0001584622,0.00005650327,0.001022164,0.000982201,0.000315007,0.0001353988,0.0002665925,0.000002305378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961921,"about_ca_system_score_gemma":0.0006422521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007465502,"about_ca_topic_score_gemma":0.0002562463,"domain_scores_codex":[0.9957556,0.001333138,0.0004525504,0.0008563552,0.001170195,0.0004321461],"domain_scores_gemma":[0.9983082,0.0002831655,0.0001637247,0.0003714947,0.0003261119,0.0005473477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006837857,0.001019741,0.9363005,0.0001314513,0.0001419998,0.0001193003,0.001278319,0.05717472,0.001500324,0.0001973565,0.00004225312,0.001410217],"study_design_scores_gemma":[0.004241148,0.005412237,0.9764393,0.0001137008,0.0001267912,0.00001804309,0.003116324,0.009260724,0.0008969546,0.0001259781,0.00004000185,0.0002087833],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946868,0.001339287,0.00005364613,0.0002016398,0.00007163789,0.003365437,0.00002030578,0.00004750375,0.0002136747],"genre_scores_gemma":[0.9992312,0.000008063536,0.0001755943,0.00008904461,0.00009580867,0.0003623297,0.00001326647,0.00001017913,0.00001447021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04791399,"threshold_uncertainty_score":0.64619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04785999933330905,"score_gpt":0.3099078336086535,"score_spread":0.2620478342753445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}