{"id":"W2254323136","doi":"10.1093/toxsci/kfv243","title":"An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe<sup>−/−</sup>Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada","keywords":"Medicine; Inflammation; COPD; Lung; Smoking cessation; Nicotine; Inhalation; Physiology; Metaplasia; Inhalation exposure; Pathology; Tobacco smoke; Internal medicine; Toxicity; Anesthesia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005884456,0.0009432093,0.001083582,0.0007054379,0.000555074,0.000651842,0.0005187498,0.001530746,0.001952393],"category_scores_gemma":[0.0001884581,0.0004874776,0.001027116,0.0002727916,0.0007302461,0.0006310684,0.0004183751,0.002553209,0.0007481634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005628893,"about_ca_system_score_gemma":0.0004447251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009662598,"about_ca_topic_score_gemma":0.002398866,"domain_scores_codex":[0.9994685,0.00005330314,0.00003925548,0.0002025237,0.0001196653,0.0001169052],"domain_scores_gemma":[0.9993179,0.00003808023,0.0001578988,0.00008358296,0.0001131219,0.0002894853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001709919,0.001388617,0.0009194644,0.00003985421,0.00002205392,0.0001352726,0.00005636389,0.00004973441,0.9941806,0.0000564799,0.0001021593,0.001339377],"study_design_scores_gemma":[0.0003814622,0.03217672,0.02946802,0.0000290574,0.0002777087,0.000735437,0.0003304393,0.001220209,0.9294984,0.0002710917,0.005545206,0.00006625678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948596,0.0004854005,0.00227367,0.0002107811,0.0001307693,0.0002035021,0.0009526184,0.0001253364,0.000758285],"genre_scores_gemma":[0.9602802,0.001287409,0.005722365,0.0007467159,0.0001012786,0.001201135,0.002721621,0.0001650951,0.02777425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001952393,"threshold_uncertainty_score":0.006531358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04785999933330905,"score_gpt":0.3099078336086535,"score_spread":0.2620478342753445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}