{"id":"W2254808774","doi":"10.1021/acs.orglett.5b02769","title":"Seven-Membered Ring Nucleoside Analogues: Stereoselective Synthesis and Studies on Their Conformational Properties","year":2015,"lang":"en","type":"article","venue":"Organic Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Directorate-General for Research and Innovation","keywords":"Chemistry; Stereoselectivity; Ring (chemistry); Stereochemistry; Nucleoside; Epoxide; Combinatorial chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478189,0.0001679873,0.0002146461,0.0001214936,0.00009874615,0.0001313929,0.0002620071,0.0001660789,0.001780204],"category_scores_gemma":[0.0002093804,0.00007789688,0.0001213079,0.0001460734,0.0001206984,0.0001484161,0.0001227759,0.0004257391,0.0003413886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001237086,"about_ca_system_score_gemma":0.000158588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001756276,"about_ca_topic_score_gemma":0.0002803026,"domain_scores_codex":[0.9999384,0.00001587906,0.000005816326,0.00001168712,0.00001621382,0.00001197961],"domain_scores_gemma":[0.999902,0.00002733355,0.00002136706,0.00001548063,0.00001796627,0.00001584629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002023381,0.00006689344,0.0002415853,0.0001551056,0.00001610967,0.0001802456,0.0000512416,0.001793985,0.9826074,0.001088106,0.0001074275,0.01348957],"study_design_scores_gemma":[0.00003517135,0.00121949,0.001058628,0.00001090205,0.00002851919,0.0004737285,0.0000178826,0.00148997,0.9883308,0.0001885776,0.007129131,0.00001706981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820372,0.003968238,0.007043524,0.00005426526,0.00002386222,0.00008636743,0.0004233823,0.00005192996,0.006311104],"genre_scores_gemma":[0.9842989,0.003101338,0.009712291,0.00004351625,0.00001166898,0.00006905582,0.0004986269,0.00002331048,0.002241226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780204,"threshold_uncertainty_score":0.005955398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0483592539318408,"score_gpt":0.2496609631248015,"score_spread":0.2013017091929607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}