{"id":"W2255008104","doi":"10.1038/ncomms10515","title":"A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":482,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre; Canadian Institutes of Health Research; Austrian Science Fund","keywords":"Bacterial outer membrane; Biogenesis; Biology; Cell biology; Bacteria; Gram-negative bacteria; Vesicle; Microbiology; Periplasmic space; Bama; ATP-binding cassette transporter; Biochemistry; Transporter; Membrane; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003389848,0.0004810035,0.0005336692,0.0004205902,0.0006339777,0.00111804,0.0004262434,0.001227297,0.0004170241],"category_scores_gemma":[0.000250735,0.000245727,0.000563464,0.0001555418,0.0006378429,0.001438951,0.0008280145,0.0005973038,0.0003551958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005633769,"about_ca_system_score_gemma":0.0003383665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000211368,"about_ca_topic_score_gemma":0.0001876721,"domain_scores_codex":[0.9997539,0.00003254307,0.00002395707,0.00007740025,0.0000679532,0.00004423064],"domain_scores_gemma":[0.9998335,0.0000146776,0.00004353451,0.00003877316,0.00003218592,0.00003735677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009355933,0.00001729733,0.0007691993,0.0002461354,0.00001654246,0.0004378752,0.00006673107,0.0001854667,0.9858182,0.006707306,0.0001540085,0.005487666],"study_design_scores_gemma":[0.00006305913,0.0007159851,0.01178642,0.00008974562,0.00006319809,0.005256465,0.0002379376,0.01020915,0.942596,0.008195868,0.02070363,0.00008271429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.839551,0.02684065,0.1256839,0.00191487,0.0007916333,0.0001617155,0.0003775499,0.000950175,0.003728456],"genre_scores_gemma":[0.9518166,0.00572704,0.0387974,0.0002973568,0.0001191427,0.00007947757,0.0003470663,0.0000561585,0.002759835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227297,"threshold_uncertainty_score":0.004087627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02844856933340779,"score_gpt":0.2864862806003804,"score_spread":0.2580377112669727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}