{"id":"W2255389810","doi":"10.1161/atvb.34.suppl_1.626","title":"Abstract 626: The ABCA1 Agonist Peptides CS-6253 and ATI-5261 Replicate ApoA-I Function and Generate nHDL Particles that Are Remodeled and Maturated Within the Plasma Compartment, Resulting in Efficient Cholesterol SR-BI Delivery to Hepatic Cells","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cholesterol; Internal medicine; Endocrinology; Apolipoprotein B; Medicine; Triglyceride; ABCA1; Chemistry; Biochemistry; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128471,0.000364118,0.0002501701,0.00007655251,0.00007695235,0.0002117888,0.0001302278,0.0002503545,0.003576674],"category_scores_gemma":[0.0001262505,0.00008225302,0.0001695357,0.00009284301,0.0001612599,0.0001944299,0.0001334988,0.0004739971,0.0009292809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137373,"about_ca_system_score_gemma":0.0001331979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005346579,"about_ca_topic_score_gemma":0.0002906842,"domain_scores_codex":[0.9998844,0.00001969039,0.00001492674,0.00002187699,0.00003136057,0.00002779508],"domain_scores_gemma":[0.9998964,0.00001702818,0.00002866128,0.00001161537,0.00001507221,0.00003125298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002328303,0.00002097276,0.0000796329,0.00001450667,0.000002237515,0.0000207955,0.000003470283,0.00002467119,0.9989501,0.00002875736,0.00002608776,0.00059601],"study_design_scores_gemma":[0.00003609228,0.0004895948,0.001657962,0.000002592958,0.000007640965,0.00020773,0.000009740172,0.0003228395,0.9962568,0.00001372432,0.0009926943,0.000002534999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961592,0.0005148613,0.001128609,0.00005747112,0.00002675537,0.00002788419,0.0003401007,0.00003299511,0.001712175],"genre_scores_gemma":[0.9940527,0.0002590075,0.001731524,0.00008932708,0.00001590452,0.00002380957,0.000608547,0.00001546552,0.003203817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003576674,"threshold_uncertainty_score":0.01196516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0405146658475726,"score_gpt":0.2581643241823276,"score_spread":0.217649658334755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}