{"id":"W2255725242","doi":"10.1074/jbc.m115.677757","title":"Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P)","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Novartis Stiftung für Medizinisch-Biologische Forschung; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Subtilisin; Biochemistry; Chemistry; Cell biology; Drosophila melanogaster; Protein structure; Protease; Protein folding; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200344,0.0003272827,0.0001639455,0.0001170715,0.0001639036,0.0002264542,0.0001880829,0.0003314514,0.0004868908],"category_scores_gemma":[0.00006194957,0.0001124929,0.0002653077,0.00006784513,0.0001753796,0.0002267392,0.0001981406,0.0002694429,0.0003671266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002714016,"about_ca_system_score_gemma":0.0001712042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002986128,"about_ca_topic_score_gemma":0.0001432017,"domain_scores_codex":[0.999917,0.00001211105,0.000006970309,0.00002642566,0.00001686045,0.00002065881],"domain_scores_gemma":[0.9999574,0.000005358348,0.00001533,0.000004716628,0.000005312949,0.00001172775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001714521,0.00002185919,0.000696425,0.00007745594,0.000006789475,0.0003639086,0.0000355095,0.0003390181,0.9945239,0.0008785111,0.00008656713,0.002798716],"study_design_scores_gemma":[0.00002926176,0.0002115026,0.006376598,0.000008581587,0.00001349536,0.001692359,0.00004507714,0.006131525,0.982079,0.0004952793,0.002907471,0.000009807998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895911,0.002881125,0.00562613,0.000137454,0.00002980659,0.00004162455,0.0001345426,0.00008357368,0.001474745],"genre_scores_gemma":[0.995433,0.0008991365,0.002192622,0.00002064026,0.000007026406,0.00001517907,0.0001383361,0.000004758623,0.00128946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004868908,"threshold_uncertainty_score":0.001969099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02569536440298733,"score_gpt":0.240680890507677,"score_spread":0.2149855261046897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}