{"id":"W2255764863","doi":"10.1021/jacs.5b12695","title":"Biomimetic Design Results in a Potent Allosteric Inhibitor of Dihydrodipicolinate Synthase from <i>Campylobacter jejuni</i>","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Campylobacter jejuni; Allosteric regulation; Campylobacter; Microbiology; Biochemistry; Stereochemistry; Enzyme; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135252,0.0003121012,0.0002070694,0.00007729198,0.00007624027,0.0002422726,0.0003161709,0.0002937625,0.0007778874],"category_scores_gemma":[0.0001375535,0.0001803158,0.0001765573,0.00009341661,0.0001466705,0.0001369756,0.000139492,0.0003429276,0.0003460747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003457447,"about_ca_system_score_gemma":0.0001579488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004600348,"about_ca_topic_score_gemma":0.0007277941,"domain_scores_codex":[0.9998947,0.00001358771,0.00001272703,0.00002504019,0.0000286796,0.00002517826],"domain_scores_gemma":[0.9999239,0.000008311931,0.00002998607,0.000005489986,0.0000105644,0.00002157786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008257308,0.00003849608,0.00005514625,0.00003128697,0.000005249052,0.00003320377,0.000005568081,0.0003466842,0.9976521,0.0001100647,0.00004723436,0.001592352],"study_design_scores_gemma":[0.00003879077,0.0003342898,0.0004126775,0.000003138101,0.00001435572,0.0001364587,0.000004295859,0.001260605,0.9940001,0.00001893543,0.003771436,0.000005014476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812417,0.00114674,0.01278793,0.0002750965,0.00008499424,0.0001258928,0.0002951338,0.0002643655,0.003778017],"genre_scores_gemma":[0.9812844,0.0006661396,0.01460935,0.0001440378,0.0000139489,0.00006072015,0.0004142258,0.00004779908,0.002759323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007778874,"threshold_uncertainty_score":0.002602339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151146680774045,"score_gpt":0.2264648988863682,"score_spread":0.2149534320786278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}