{"id":"W2255905287","doi":"10.1038/tp.2015.205","title":"Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins","year":2016,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Innovative Medicines Initiative; King's College London; John Douglas French Alzheimer's Foundation; European Federation of Pharmaceutical Industries and Associations; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Eisai; South London and Maudsley NHS Foundation Trust; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of California, San Francisco; Alzheimer's Society; University of Southern California; European Commission; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Metabolomics; Alzheimer's Disease Neuroimaging Initiative; Disease; Biomarker; Metabolite; Alzheimer's disease; Amyloid (mycology); Medicine; Dementia; Fibrinogen; Neuroimaging; Bioinformatics; Pathology; Internal medicine; Biology; Psychiatry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120566,0.000141048,0.0001826479,0.00005485984,0.00005828564,0.00001147781,0.0000733745,0.00006808027,0.00001980476],"category_scores_gemma":[0.00001373444,0.00009903429,0.0000904687,0.00007501624,0.0001184447,0.00001046334,0.00003104669,0.00003914084,5.703702e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003108316,"about_ca_system_score_gemma":0.00009493581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003338155,"about_ca_topic_score_gemma":0.00002097858,"domain_scores_codex":[0.9990929,0.00003540778,0.0002544979,0.0002799198,0.0001555414,0.0001817706],"domain_scores_gemma":[0.999647,0.00001360027,0.00007963117,0.0001654921,0.00003503628,0.00005919864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002899991,0.00008518398,0.03875557,0.00003875791,0.0003679959,4.24046e-7,0.0000174808,0.00001932433,0.9402388,0.01909601,0.000042595,0.001047884],"study_design_scores_gemma":[0.01288927,0.001588901,0.6368367,0.0002214043,0.001499522,0.00009818146,0.0002246734,0.0002565304,0.2949304,0.02423468,0.02551055,0.001709245],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820277,0.005103674,0.010343,0.001556654,0.0001904763,0.0002204269,0.0001504789,0.000004983884,0.0004026037],"genre_scores_gemma":[0.9868395,0.0007415494,0.01186142,0.00006661283,0.0002694686,0.00001124469,0.00002110732,0.00001383572,0.0001752232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6453084,"threshold_uncertainty_score":0.4038501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00809717902480737,"score_gpt":0.2456587015634678,"score_spread":0.2375615225386604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}