{"id":"W2255905287","doi":"10.1038/tp.2015.205","title":"Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins","year":2016,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Innovative Medicines Initiative; King's College London; John Douglas French Alzheimer's Foundation; European Federation of Pharmaceutical Industries and Associations; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Eisai; South London and Maudsley NHS Foundation Trust; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of California, San Francisco; Alzheimer's Society; University of Southern California; European Commission; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Metabolomics; Alzheimer's Disease Neuroimaging Initiative; Disease; Biomarker; Metabolite; Alzheimer's disease; Amyloid (mycology); Medicine; Dementia; Fibrinogen; Neuroimaging; Bioinformatics; Pathology; Internal medicine; Biology; Psychiatry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001003201,0.0006768849,0.0007206344,0.001174881,0.0002967366,0.000880738,0.000214669,0.0003506152,0.00102505],"category_scores_gemma":[0.00237147,0.000128093,0.000630827,0.0009261456,0.0002018611,0.0003579942,0.0004173856,0.0003302374,0.0003125211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958821,"about_ca_system_score_gemma":0.0003701252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001378162,"about_ca_topic_score_gemma":0.003128592,"domain_scores_codex":[0.9997116,0.0001296348,0.00001577146,0.00007355174,0.00003744241,0.00003207543],"domain_scores_gemma":[0.9993497,0.0003152846,0.000155943,0.0000602884,0.00005917201,0.00005961006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002034686,0.0003730906,0.8657242,0.000157911,0.001250386,0.0005407121,0.0001300651,0.003195867,0.06016957,0.0002675911,0.0005428703,0.06561309],"study_design_scores_gemma":[0.0001458936,0.001092608,0.924083,0.00004309861,0.001014727,0.001703706,0.0002037327,0.04414348,0.02263276,0.002794263,0.002077691,0.00006512109],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906077,0.0009915143,0.007107719,0.0002068076,0.000007821996,0.00003227784,0.0005225811,0.00007395346,0.0004496782],"genre_scores_gemma":[0.9919373,0.0003627944,0.006964934,0.00006121547,0.00001276381,0.00001800308,0.0003973599,0.00001120392,0.0002343751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378162,"threshold_uncertainty_score":0.005305529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00809717902480737,"score_gpt":0.2456587015634678,"score_spread":0.2375615225386604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}