{"id":"W2256084926","doi":"10.1021/acschemneuro.5b00115","title":"<i>N</i>-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Hong Kong; Research Grants Council, University Grants Committee","keywords":"Hydroxydopamine; Neurite; Nerve growth factor; Chemistry; Pharmacology; Cell biology; Neuroscience; Dopamine; Biology; Biochemistry; Dopaminergic; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009626283,0.0004147494,0.0002057634,0.0001380053,0.0001406558,0.000133073,0.000174705,0.0002193228,0.0008416617],"category_scores_gemma":[0.00008185451,0.00006509281,0.0002797476,0.0001160118,0.000171173,0.0003077642,0.0001229899,0.0003018775,0.000225362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001666515,"about_ca_system_score_gemma":0.0001469979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006020057,"about_ca_topic_score_gemma":0.0007984031,"domain_scores_codex":[0.9999406,0.000009525691,0.000004473309,0.00001491288,0.00001345664,0.00001686682],"domain_scores_gemma":[0.9999532,0.000005243352,0.00001813751,0.000004420907,0.000008868808,0.00001024521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001036641,0.00001467639,0.00005032951,0.00005994039,0.000006331186,0.00005343572,0.000003961688,0.00003740578,0.9985404,0.00005411993,0.00003319536,0.001042516],"study_design_scores_gemma":[0.000006792392,0.0003059799,0.001041297,0.000002537352,0.00001271186,0.0002008274,0.000005387176,0.0002075393,0.9967709,0.00002139625,0.001421213,0.000003426195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809433,0.007239138,0.007049224,0.0002668418,0.00007513739,0.00005659834,0.0003015892,0.000116491,0.003951708],"genre_scores_gemma":[0.9916196,0.0023865,0.004047879,0.00010397,0.00002844675,0.00002323715,0.0002884009,0.00002041025,0.001481521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008416617,"threshold_uncertainty_score":0.002815604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774354199279178,"score_gpt":0.244456281625063,"score_spread":0.2167127396322712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}