{"id":"W2256084926","doi":"10.1021/acschemneuro.5b00115","title":"<i>N</i>-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Hong Kong; Research Grants Council, University Grants Committee","keywords":"Hydroxydopamine; Neurite; Nerve growth factor; Chemistry; Pharmacology; Cell biology; Neuroscience; Dopamine; Biology; Biochemistry; Dopaminergic; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002896719,0.0004994292,0.0003804229,0.00004277933,0.0002737183,0.0001902934,0.000932596,0.0002282786,0.000001675542],"category_scores_gemma":[0.001605239,0.0003862633,0.0001167006,0.000293712,0.0005225334,0.00005469808,0.0007891333,0.0004362782,0.000004584876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003671262,"about_ca_system_score_gemma":0.00009712167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008399507,"about_ca_topic_score_gemma":0.000005064323,"domain_scores_codex":[0.9969304,0.0001501332,0.0004403069,0.001224364,0.0004670742,0.0007877732],"domain_scores_gemma":[0.9983785,0.0001005447,0.0002829272,0.0006057992,0.0002279875,0.0004042215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006160289,0.0001032444,0.004263316,0.0000188273,0.00001084405,0.000007260056,0.00009696459,0.000002354609,0.9942703,0.00001043504,0.0006423695,0.0005124689],"study_design_scores_gemma":[0.0007044169,0.0002753289,0.002250144,0.00001713047,0.00001411432,0.0000377299,0.00008949403,0.0001741982,0.9953578,0.0001614827,0.0004452031,0.0004729808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976065,0.0002101735,0.0001075465,0.001093697,0.0002560587,0.0003726652,0.000115777,0.00005208783,0.0001855665],"genre_scores_gemma":[0.9976994,0.00007358156,0.000106886,0.001591069,0.0002618681,0.00003746361,0.00006806757,0.00005362318,0.0001080662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013172,"threshold_uncertainty_score":0.9998589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774354199279178,"score_gpt":0.244456281625063,"score_spread":0.2167127396322712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}