{"id":"W2256206968","doi":"10.1021/jm100095x","title":"Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase<sup>⊥</sup>⊥ Atomic coordinates and structure factors for crystal structure of compound<b>3d</b>with p38α can be accessed using PDB code 3LHJ.","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Chemistry; Proinflammatory cytokine; Protein kinase A; Kinase; Arthritis; Tumor necrosis factor alpha; p38 mitogen-activated protein kinases; Signal transduction; Mitogen-activated protein kinase; Biochemistry; Pharmacology; Immunology; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398219,0.0005390317,0.0003999843,0.0002661247,0.0001785558,0.0002948334,0.0004078658,0.0003036359,0.001271078],"category_scores_gemma":[0.0001610538,0.000155306,0.0002328193,0.0002191176,0.0002649692,0.0002440238,0.0001605968,0.0004740974,0.0004535879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817178,"about_ca_system_score_gemma":0.0004673893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001187481,"about_ca_topic_score_gemma":0.002927166,"domain_scores_codex":[0.9998913,0.00001706592,0.000006552835,0.00001544658,0.00003395061,0.00003562897],"domain_scores_gemma":[0.9999336,0.000006632225,0.00001837473,0.000005193177,0.00001332972,0.00002288707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001268936,0.001401503,0.0007578873,0.0003953461,0.00004323752,0.0006272601,0.0001185151,0.003247623,0.9138219,0.001396855,0.002083504,0.07483751],"study_design_scores_gemma":[0.002310305,0.02233852,0.006356782,0.00006371448,0.0001332791,0.00251894,0.00005619084,0.004471107,0.929982,0.0003573596,0.03134302,0.00006879113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964628,0.01763649,0.007399209,0.0004794234,0.0001104727,0.0006808556,0.001366849,0.000277788,0.007420911],"genre_scores_gemma":[0.968628,0.01370867,0.01005859,0.0002029376,0.00004258032,0.000205646,0.001999707,0.00002866269,0.005125175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271078,"threshold_uncertainty_score":0.004252136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173595285359172,"score_gpt":0.2564363059530085,"score_spread":0.2447003530994168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}