{"id":"W2256206968","doi":"10.1021/jm100095x","title":"Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase<sup>⊥</sup>⊥ Atomic coordinates and structure factors for crystal structure of compound<b>3d</b>with p38α can be accessed using PDB code 3LHJ.","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Chemistry; Proinflammatory cytokine; Protein kinase A; Kinase; Arthritis; Tumor necrosis factor alpha; p38 mitogen-activated protein kinases; Signal transduction; Mitogen-activated protein kinase; Biochemistry; Pharmacology; Immunology; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003005786,0.0003116775,0.0006048942,0.00007770141,0.00008530963,0.00002529086,0.0001683523,0.0003461991,0.000006846061],"category_scores_gemma":[0.0004201979,0.0002270778,0.00007644964,0.0001153829,0.0004176099,0.00003562576,0.00007270413,0.0003448326,2.000288e-9],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003470524,"about_ca_system_score_gemma":0.0006554239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009179428,"about_ca_topic_score_gemma":0.00004678208,"domain_scores_codex":[0.9983415,0.00005214106,0.0005746624,0.0003175713,0.0004955619,0.000218534],"domain_scores_gemma":[0.9973639,0.00006960404,0.001387228,0.0001820074,0.0008395726,0.0001577503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001583,0.00005880255,0.01171802,0.0006842698,0.0002755073,0.00000608214,0.0003660277,0.0001483001,0.9849278,0.000003557486,0.00003023591,0.000198407],"study_design_scores_gemma":[0.003873736,0.0009842014,0.004065948,0.0002690436,0.0003922046,0.0004699839,0.0009112435,0.0004106787,0.9882735,0.00009687585,0.00003255115,0.00022006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981772,0.0007707661,0.00005507096,0.00006951691,0.00007941049,0.0004277936,0.0004109678,0.000003178678,0.000006123619],"genre_scores_gemma":[0.9990863,0.00003483789,0.0005213496,0.00000981081,0.0002019751,0.000002580784,0.0001040206,0.00002976739,0.000009331622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007652069,"threshold_uncertainty_score":0.9259962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173595285359172,"score_gpt":0.2564363059530085,"score_spread":0.2447003530994168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}