{"id":"W2256630453","doi":"10.21542/gcsp.2017.2","title":"The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol","year":2017,"lang":"en","type":"review","venue":"Global Cardiology Science and Practice","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Fondation Leducq","keywords":"Ezetimibe; Medicine; Familial hypercholesterolemia; Simvastatin; PCSK9; Cholesterol; Statin; Internal medicine; Disease; Incidence (geometry); Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001428382,0.0005617451,0.0006029058,0.000642054,0.0005053104,0.002236474,0.0007142196,0.003883884,0.01666059],"category_scores_gemma":[0.006118854,0.0002176793,0.0009330142,0.0003458829,0.001012618,0.001842118,0.0006929408,0.007130517,0.008227467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008477636,"about_ca_system_score_gemma":0.001349482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001397879,"about_ca_topic_score_gemma":0.002102211,"domain_scores_codex":[0.998933,0.0002516625,0.0001294756,0.0001572731,0.0004186488,0.0001099306],"domain_scores_gemma":[0.9975178,0.001288974,0.0001686249,0.00008318237,0.0007506174,0.0001908227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003661096,0.00004028894,0.000158585,0.001203356,0.00006080647,0.0002546312,0.000060852,0.00007556245,0.0009494796,0.01014398,0.8753703,0.111316],"study_design_scores_gemma":[0.00008862711,0.0001061021,0.0005557493,0.0006122408,0.0000358242,0.0003812492,0.00002681955,0.00007724998,0.0004971054,0.003053287,0.9945496,0.0000160947],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.001867324,0.262555,0.00151886,0.3898129,0.3068514,0.00009886858,0.0009184581,0.0002699092,0.03610722],"genre_scores_gemma":[0.01868246,0.269802,0.002146741,0.3127649,0.3297048,0.0001825013,0.0007337942,0.0002476181,0.06573526],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01666059,"threshold_uncertainty_score":0.05573529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06475592584950879,"score_gpt":0.4073453454190859,"score_spread":0.3425894195695771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}