{"id":"W2256636924","doi":"10.1200/jco.2009.27.15_suppl.5012","title":"Mature results of a randomized phase II study of OGX-011 in combination with docetaxel/prednisone versus docetaxel/prednisone in patients with metastatic castration-resistant prostate cancer","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre; Juravinski Cancer Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Docetaxel; Clinical endpoint; Prednisone; Internal medicine; Clusterin; Urology; Gastroenterology; Prostate cancer; Oncology; Surgery; Chemotherapy; Cancer; Randomized controlled trial; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003015781,0.001541342,0.002575703,0.0003827308,0.0004264959,0.001136144,0.0009116486,0.001424435,0.006114201],"category_scores_gemma":[0.002104798,0.000713077,0.002017896,0.000484619,0.001230343,0.0009125768,0.0003415338,0.002851318,0.001024083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009835534,"about_ca_system_score_gemma":0.001626603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092807,"about_ca_topic_score_gemma":0.002528868,"domain_scores_codex":[0.9985182,0.001006573,0.00007521635,0.0001519879,0.0000856648,0.0001623332],"domain_scores_gemma":[0.9980479,0.0005193661,0.0003732323,0.0001672461,0.0001080682,0.0007841439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9615102,0.01411311,0.0009909465,0.0002487857,0.000760416,0.00005221734,0.00005114007,0.0004809807,0.005386221,0.00004690604,0.0006852071,0.01567381],"study_design_scores_gemma":[0.778643,0.2148944,0.004252385,0.00002145962,0.0005930222,0.00004434483,0.00001927217,0.0002572271,0.000590871,0.00007090867,0.0005983214,0.00001472857],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898286,0.002178541,0.0005357804,0.0005662565,0.0002805644,0.003295071,0.001292825,0.00005490274,0.001967449],"genre_scores_gemma":[0.9873641,0.001579054,0.001203959,0.001009323,0.0004361833,0.003211421,0.002475674,0.00003155191,0.00268865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006114201,"threshold_uncertainty_score":0.02045411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06752239049819722,"score_gpt":0.4470934402889443,"score_spread":0.3795710497907471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}