{"id":"W2257212963","doi":"","title":"The human cathelicidin, LL-37, kills through activation of the mitochondrial-associated pathway of apoptosis in a caspase-independent manner","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"","keywords":"Jurkat cells; Cathelicidin; Apoptosis; Biology; Cell biology; Caspase; Programmed cell death; DNA fragmentation; Inhibitor of apoptosis domain; Molecular biology; Innate immune system; Immunology; T cell; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351982,0.000284766,0.00017778,0.0001422326,0.0001164861,0.0002681656,0.000133646,0.0002175471,0.0007808454],"category_scores_gemma":[0.0001304393,0.00006702918,0.0002248473,0.0001374026,0.0001723525,0.0001983462,0.0002107204,0.0003879503,0.0002529325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003677382,"about_ca_system_score_gemma":0.0002166027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003967069,"about_ca_topic_score_gemma":0.0003683464,"domain_scores_codex":[0.9997626,0.00005056147,0.00002903365,0.00003530598,0.00006037299,0.00006199904],"domain_scores_gemma":[0.9999303,0.00001116307,0.00002032834,0.00001255885,0.00001193174,0.00001367455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001262589,0.00002207147,0.0002022667,0.0000439266,0.000004338009,0.00006996493,0.00001343492,0.00004128691,0.9979573,0.000127263,0.00003855677,0.001353416],"study_design_scores_gemma":[0.00002514378,0.0002942247,0.002865589,0.00001100273,0.00001001158,0.0005357895,0.00002194714,0.0008219404,0.9922338,0.00006708803,0.003110201,0.000003231142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865747,0.004072472,0.006429131,0.0001442775,0.00004521625,0.00006942121,0.0005900914,0.00008704746,0.001987706],"genre_scores_gemma":[0.9929832,0.001567602,0.002684608,0.00006430254,0.00001059065,0.00004709507,0.0004970743,0.000005449841,0.00214022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007808454,"threshold_uncertainty_score":0.002668083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808079910193044,"score_gpt":0.266549425651146,"score_spread":0.2484686265492155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}