{"id":"W2257382202","doi":"10.1155/2016/8253726","title":"Evaluating the Effects of Tetrachloro-1,4-benzoquinone, an Active Metabolite of Pentachlorophenol, on the Growth of Human Breast Cancer Cells","year":2016,"lang":"en","type":"article","venue":"Journal of Toxicology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"College of Pharmacy and Nutrition, University of Saskatchewan; University of Saskatchewan","keywords":"Cytotoxicity; Apoptosis; Pentachlorophenol; Oxidative stress; Intracellular; Metabolite; Chemistry; Reactive oxygen species; Cancer cell; DNA damage; Cancer research; Biochemistry; Pharmacology; Biology; Cancer; In vitro; DNA; Environmental chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001549441,0.0002297833,0.0006676207,0.0001679591,0.0001971549,0.0000061438,0.000742947,0.0002147993,0.0008700229],"category_scores_gemma":[0.0002182989,0.0001088541,0.0002887903,0.0001975388,0.0008267703,0.0001745043,0.0001117575,0.0006420597,0.000002933576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008334259,"about_ca_system_score_gemma":0.0001689589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003123486,"about_ca_topic_score_gemma":0.0000147008,"domain_scores_codex":[0.9966419,0.001640027,0.0008286843,0.0001932285,0.0003645296,0.0003315941],"domain_scores_gemma":[0.9947004,0.002442903,0.001856386,0.0002466484,0.000632311,0.0001213947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00156474,0.00115398,0.007619995,0.0001025365,0.0007743407,0.00001519988,0.0006904404,0.00002265561,0.9755839,0.002076664,0.0003972535,0.009998312],"study_design_scores_gemma":[0.002220844,0.003319584,0.09024925,0.000113813,0.0005549258,0.00005246997,0.0002118108,0.00003374746,0.9021736,0.0008293086,0.0001267881,0.0001138242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955401,0.0005294496,0.00001889796,0.001515688,0.001581547,0.0003613161,0.0001447102,0.000004374142,0.0003039609],"genre_scores_gemma":[0.998445,0.000429363,0.00004601645,0.0006103813,0.0003367458,0.00001376119,7.311133e-7,0.00002081057,0.00009723369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08262925,"threshold_uncertainty_score":0.9526141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1352291607677549,"score_gpt":0.4666301887971941,"score_spread":0.3314010280294393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}