{"id":"W2257545295","doi":"10.1016/j.jaad.2015.12.017","title":"Comparative effectiveness of biologic agents for the treatment of psoriasis in a real-world setting: Results from a large, prospective, observational study (Psoriasis Longitudinal Assessment and Registry [PSOLAR])","year":2016,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Innovaderm (Canada); Probity Medical Research","funders":"Medac; Janssen Scientific Affairs; Eli Lilly and Company; Galderma; Incyte; Dermira; University of Connecticut; Celgene; Amgen; Pfizer; GlaxoSmithKline; Abbott Laboratories","keywords":"Ustekinumab; Medicine; Adalimumab; Etanercept; Infliximab; Psoriasis; Internal medicine; Observational study; Psoriasis Area and Severity Index; Body surface area; Odds ratio; Dermatology; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01372401,0.0004210474,0.0007000516,0.0009585991,0.0004010203,0.001028739,0.0006757784,0.0006830579,0.001023582],"category_scores_gemma":[0.0182183,0.000288333,0.001146736,0.001075792,0.0005889311,0.0009587671,0.0005995242,0.0008574238,0.0002093289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005202998,"about_ca_system_score_gemma":0.0004950051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204609,"about_ca_topic_score_gemma":0.001276456,"domain_scores_codex":[0.9814849,0.01302096,0.001546194,0.001677602,0.00181694,0.00045348],"domain_scores_gemma":[0.9673288,0.01071432,0.01713326,0.002332797,0.00107087,0.001419875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006945836,0.0007337675,0.9847746,0.0001140645,0.002442745,0.00003217926,0.0001154849,0.0001451589,0.0002434302,0.00005001562,0.000220389,0.004182347],"study_design_scores_gemma":[0.00149012,0.005942571,0.9894227,0.00003625833,0.0009435794,0.0003157808,0.0001939069,0.0006187997,0.0003454378,0.00005639764,0.0006083445,0.00002600845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968556,0.001817443,0.0002591682,0.00005798137,0.00001896579,0.00005381721,0.0006547926,0.000006244748,0.000275891],"genre_scores_gemma":[0.9981483,0.0003715794,0.0002562018,0.00006084984,0.00003381749,0.00005062369,0.001029842,0.000003394896,0.00004544968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01372401,"threshold_uncertainty_score":0.0725804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09110685648330386,"score_gpt":0.3823672007373807,"score_spread":0.2912603442540768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}