{"id":"W2257921434","doi":"10.1371/journal.ppat.1005356","title":"Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Clinical and Translational Science Institute, University of California, Los Angeles; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of California Los Angeles; National Institute of General Medical Sciences; Center for AIDS Research, University of Washington; National Human Genome Research Institute; National Cancer Institute; National Institutes of Health","keywords":"Lymphocytic choriomeningitis; Immunology; Biology; Immunosuppression; T cell; Dendritic cell; Interferon type I; Interferon; Chronic infection; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007880107,0.0001748942,0.0002067275,0.00008436406,0.0003390017,0.00001651516,0.00008887718,0.0001672024,0.0003122955],"category_scores_gemma":[0.00007058115,0.0001275238,0.00003459262,0.00007760029,0.0002376883,0.0001511632,0.0001270022,0.0001271009,0.0001248061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000265548,"about_ca_system_score_gemma":0.0000240794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005414321,"about_ca_topic_score_gemma":0.00000150461,"domain_scores_codex":[0.999034,0.0001715789,0.0001720443,0.0002948616,0.00002617619,0.0003012897],"domain_scores_gemma":[0.999508,0.00008846512,0.0000727208,0.0002034791,0.0001059605,0.00002140644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002470874,0.00005675322,0.00128721,0.00003177436,0.0001136628,0.000009888126,0.0005809222,1.281346e-7,0.9931881,0.00002840285,0.00007224303,0.002159991],"study_design_scores_gemma":[0.001728131,0.001539237,0.02562556,0.0001562173,0.0001050573,0.0001441803,0.0002504444,0.000002284016,0.9678434,0.00005096982,0.00231295,0.0002416338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879892,0.0110288,0.00001454623,0.0001212546,0.000438213,0.0001385443,0.00002356099,0.00005397967,0.000191826],"genre_scores_gemma":[0.9876811,0.001218644,0.00001894222,0.00004303169,0.00001722469,0.000006602904,0.00001132857,0.00002171744,0.01098143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02534481,"threshold_uncertainty_score":0.5200271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152150266345312,"score_gpt":0.2027067416173907,"score_spread":0.1874917149828595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}