{"id":"W2257921434","doi":"10.1371/journal.ppat.1005356","title":"Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Clinical and Translational Science Institute, University of California, Los Angeles; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of California Los Angeles; National Institute of General Medical Sciences; Center for AIDS Research, University of Washington; National Human Genome Research Institute; National Cancer Institute; National Institutes of Health","keywords":"Lymphocytic choriomeningitis; Immunology; Biology; Immunosuppression; T cell; Dendritic cell; Interferon type I; Interferon; Chronic infection; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398083,0.0002083562,0.0001860346,0.0001759047,0.0001346856,0.0004937671,0.0001449315,0.0001861038,0.0004285988],"category_scores_gemma":[0.0001180259,0.00009487861,0.0001032226,0.0001190236,0.0002511401,0.0002174181,0.0002265667,0.0003587691,0.0001823998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003211125,"about_ca_system_score_gemma":0.000216459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002148609,"about_ca_topic_score_gemma":0.0003633011,"domain_scores_codex":[0.999856,0.00002197867,0.00001016326,0.00003164677,0.00003201502,0.00004813519],"domain_scores_gemma":[0.9999051,0.00001164469,0.00003061163,0.00001348607,0.00001466839,0.00002442093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001556765,0.00001418913,0.0009481894,0.00001520294,0.000001534405,0.00006390815,0.00002507512,0.00006217948,0.9957446,0.0004306745,0.00003330044,0.002505424],"study_design_scores_gemma":[0.00002406604,0.000242345,0.02531697,0.00001478531,0.00002116852,0.0005198825,0.0001821693,0.002389143,0.9639748,0.0007615485,0.006544739,0.000008483773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905422,0.002459555,0.004530234,0.00007564102,0.00003585809,0.00001465255,0.0001574042,0.00007275699,0.002111632],"genre_scores_gemma":[0.9961374,0.0008327945,0.001198811,0.00003037488,0.00001497667,0.00002004666,0.0001012873,0.00001541651,0.00164881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004937671,"threshold_uncertainty_score":0.002329767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152150266345312,"score_gpt":0.2027067416173907,"score_spread":0.1874917149828595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}